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NkG2C & EGFR Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0725-N97 Recombinant Human Anti-NkG2C x Mouse Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2C Human EGFR Mouse Inquiry
KN-0725-N61 Recombinant Human Anti-NkG2C x Mouse Anti-EGFR Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human EGFR Mouse Inquiry
KN-0725-N23 Recombinant Human Anti-NkG2C x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human EGFR Mouse Inquiry
FABIG-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Mouse HER2 Mouse Inquiry
FABIG-154 Recombinant Anti-EGFR x Anti-MET Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Mouse MET Mouse Inquiry
FABIG-151 Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG doxorubicin Mouse EGFR Mouse Inquiry
FABIG-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Mouse EGFR Mouse Inquiry
FABIG-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD64 Mouse EGFR Mouse Inquiry
FABIG-077 Recombinant Anti-CD3 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse EGFR Mouse Inquiry
FABIG-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse EGFR Mouse Inquiry
FABIG-046 Recombinant Anti-CD2 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD2 Mouse EGFR Mouse Inquiry
FABIG-036 Recombinant Anti-CD16 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD16 Mouse EGFR Mouse Inquiry
FABIG-031 Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD133 Mouse EGFR Mouse Inquiry
TRIB-158 Recombinant Anti-EGFR x Anti-ZnO Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse ZnO Mouse Inquiry
TRIB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse IGF1R Mouse Inquiry
TRIB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse HER3 Mouse Inquiry
TRIB-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse HER2 Mouse Inquiry
TRIB-154 Recombinant Anti-EGFR x Anti-MET Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse MET Mouse Inquiry
TRIB-151 Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv doxorubicin Mouse EGFR Mouse Inquiry
TRIB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Mouse EGFR Mouse Inquiry
TRIB-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD64 Mouse EGFR Mouse Inquiry
TRIB-077 Recombinant Anti-CD3 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse EGFR Mouse Inquiry
TRIB-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse EGFR Mouse Inquiry
TRIB-046 Recombinant Anti-CD2 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD2 Mouse EGFR Mouse Inquiry
TRIB-036 Recombinant Anti-CD16 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD16 Mouse EGFR Mouse Inquiry
TRIB-031 Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD133 Mouse EGFR Mouse Inquiry
BSIG-158 Anti-EGFR x Anti-ZnO Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse ZnO Mouse Inquiry
BSIG-157 Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse IGF1R Mouse Inquiry
BSIG-156 Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse HER3 Mouse Inquiry
BSIG-155 Anti-EGFR x Anti-HER2 Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse HER2 Mouse Inquiry
BSIG-154 Anti-EGFR x Anti-MET Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse MET Mouse Inquiry
BSIG-151 Anti-doxorubicin x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG doxorubicin Mouse EGFR Mouse Inquiry
BSIG-132 Anti-CD89 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Mouse EGFR Mouse Inquiry
BSIG-125 Anti-CD64 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD64 Mouse EGFR Mouse Inquiry
BSIG-077 Anti-CD3 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse EGFR Mouse Inquiry
BSIG-058 Anti-CD28 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse EGFR Mouse Inquiry
BSIG-046 Anti-CD2 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD2 Mouse EGFR Mouse Inquiry
BSIG-036 Anti-CD16 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD16 Mouse EGFR Mouse Inquiry
BSIG-031 Anti-CD133 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD133 Mouse EGFR Mouse Inquiry
CROSSAB-158 Recombinant Anti-EGFR x Anti-ZnO Bispecific Antibody (CrossMab) Human CrossMab EGFR Mouse ZnO Mouse Inquiry
CROSSAB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab EGFR Mouse IGF1R Mouse Inquiry
CROSSAB-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (CrossMab) Human CrossMab EGFR Mouse HER2 Mouse Inquiry
CROSSAB-154 Recombinant Anti-EGFR x Anti-MET Bispecific Antibody (CrossMab) Human CrossMab EGFR Mouse MET Mouse Inquiry
CROSSAB-151 Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab doxorubicin Mouse EGFR Mouse Inquiry
CROSSAB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD89 Mouse EGFR Mouse Inquiry
CROSSAB-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD64 Mouse EGFR Mouse Inquiry
CROSSAB-077 Recombinant Anti-CD3 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse EGFR Mouse Inquiry
CROSSAB-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse EGFR Mouse Inquiry
CROSSAB-046 Recombinant Anti-CD2 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD2 Mouse EGFR Mouse Inquiry
CROSSAB-036 Recombinant Anti-CD16 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD16 Mouse EGFR Mouse Inquiry
CROSSAB-031 Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD133 Mouse EGFR Mouse Inquiry
IGFV-158 Recombinant Anti-EGFR x Anti-ZnO Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse ZnO Mouse Inquiry
IGFV-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse IGF1R Mouse Inquiry
IGFV-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse HER3 Mouse Inquiry
IGFV-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse HER2 Mouse Inquiry
IGFV-154 Recombinant Anti-EGFR x Anti-MET Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse MET Mouse Inquiry
IGFV-151 Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv doxorubicin Mouse EGFR Mouse Inquiry
IGFV-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Mouse EGFR Mouse Inquiry
IGFV-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 Mouse EGFR Mouse Inquiry
IGFV-077 Recombinant Anti-CD3 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse EGFR Mouse Inquiry
IGFV-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse EGFR Mouse Inquiry
IGFV-046 Recombinant Anti-CD2 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD2 Mouse EGFR Mouse Inquiry
IGFV-036 Recombinant Anti-CD16 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD16 Mouse EGFR Mouse Inquiry
IGFV-031 Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD133 Mouse EGFR Mouse Inquiry
BSDB-158 Recombinant Anti-EGFR x Anti-ZnO Bispecific Antibody (Diabody) Human Diabody EGFR Mouse ZnO Mouse Inquiry
BSDB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody EGFR Mouse IGF1R Mouse Inquiry
BSDB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody EGFR Mouse HER3 Mouse Inquiry
BSDB-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody EGFR Mouse HER2 Mouse Inquiry
BSDB-154 Recombinant Anti-EGFR x Anti-MET Bispecific Antibody (Diabody) Human Diabody EGFR Mouse MET Mouse Inquiry
BSDB-151 Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody doxorubicin Mouse EGFR Mouse Inquiry
BSDB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD89 Mouse EGFR Mouse Inquiry
BSDB-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD64 Mouse EGFR Mouse Inquiry
BSDB-077 Recombinant Anti-CD3 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD3 Mouse EGFR Mouse Inquiry
BSDB-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD28 Mouse EGFR Mouse Inquiry
BSDB-046 Recombinant Anti-CD2 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD2 Mouse EGFR Mouse Inquiry
BSDB-036 Recombinant Anti-CD16 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD16 Mouse EGFR Mouse Inquiry
BSDB-031 Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD133 Mouse EGFR Mouse Inquiry
BSFV-151 Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv doxorubicin Mouse EGFR Mouse Inquiry
BSFAB-158 Recombinant Anti-EGFR x Anti-ZnO Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse ZnO Mouse Inquiry
BSFAB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse IGF1R Mouse Inquiry
BSFAB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse HER3 Mouse Inquiry
BSFAB-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse HER2 Mouse Inquiry
BSFAB-154 Recombinant Anti-EGFR x Anti-MET Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse MET Mouse Inquiry
BSFAB-151 Recombinant Anti-doxorubicin x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab doxorubicin Mouse EGFR Mouse Inquiry
BSFAB-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Mouse EGFR Mouse Inquiry
BSFAB-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 Mouse EGFR Mouse Inquiry
BSFAB-077 Recombinant Anti-CD3 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse EGFR Mouse Inquiry
BSFAB-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse EGFR Mouse Inquiry
BSFAB-046 Recombinant Anti-CD2 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD2 Mouse EGFR Mouse Inquiry
BSFAB-036 Recombinant Anti-CD16 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD16 Mouse EGFR Mouse Inquiry
BSFAB-031 Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD133 Mouse EGFR Mouse Inquiry
BSFV-158 Recombinant Anti-EGFR x Anti-ZnO Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse ZnO Mouse Inquiry
BSFV-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse IGF1R Mouse Inquiry
BSFV-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse HER3 Mouse Inquiry
BSFV-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse HER2 Mouse Inquiry
BSFV-154 Recombinant Anti-EGFR x Anti-MET Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse MET Mouse Inquiry
BSFV-132 Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Mouse EGFR Mouse Inquiry
BSFV-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 Mouse EGFR Mouse Inquiry
BSFV-077 Recombinant Anti-CD3 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse EGFR Mouse Inquiry
BSFV-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse EGFR Mouse Inquiry
BSFV-046 Recombinant Anti-CD2 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD2 Mouse EGFR Mouse Inquiry
BSFV-036 Recombinant Anti-CD16 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD16 Mouse EGFR Mouse Inquiry
BSFV-031 Recombinant Anti-CD133 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD133 Mouse EGFR Mouse Inquiry

Background

Natural killer group 2C (NkG2C), an activating receptor of the NkG2 family, forms heterodimers with CD94 to trigger cytotoxic NK cell activation upon binding HLA-E ligands. It plays critical roles in antiviral and antitumor immunity by promoting adaptive-like NK cell responses, particularly in cytomegalovirus (CMV)-driven expansions. The epidermal growth factor receptor (EGFR), a transmembrane tyrosine kinase, drives tumor proliferation and survival through aberrant signaling in cancers like glioblastoma and non-small cell lung carcinoma. Bispecific antibody targeting NkG2C and EGFR engages NK cells while inhibiting EGFR oncogenic signaling. Mechanistically, it bridges NkG2C⁺ NK cells to EGFR⁺ tumors, enhancing antibody-dependent cellular cytotoxicity (ADCC) and suppressing EGFR-mediated survival pathways. This approach leverages NK cell surveillance to eliminate therapy-resistant malignancies, particularly in CMV-positive populations where NkG2C⁺ NK cells dominate. Applications span oncology (e.g., solid tumors, lymphomas) and infectious disease models requiring enhanced immune effector recruitment and tumor-specific targeting.

The HLA-E/peptide/β2m/NKG2C/CD94 immune complex and ligand-bound EGFR dimer structure. (OA Literature)Fig.1 Structural collage of NkG2C and EGFR.1,2

References

  1. Prašnikar, Eva et al. "Nonameric Peptide Orchestrates Signal Transduction in the Activating HLA-E/NKG2C/CD94 Immune Complex as Revealed by All-Atom Simulations." International Journal of Molecular Sciences vol. 22,13 6670. 22 Jun. 2021, doi:10.3390/ijms22136670. Distributed under Open Access license CC BY 4.0, without modification.
  2. Huang, Yongjian et al. "A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor." eLife vol. 10 e73218. 30 Nov. 2021, doi:10.7554/eLife.73218. Distributed under Open Access license CC BY 4.0. The image was modified by extracting and using only part of the original image.
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