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NkG2C & GPC3 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0725-N96 Recombinant Human Anti-NkG2C x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2C Human GPC3 Mouse Inquiry
KN-0725-N60 Recombinant Human Anti-NkG2C x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human GPC3 Mouse Inquiry
KN-0725-N22 Recombinant Human Anti-NkG2C x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human GPC3 Mouse Inquiry
KN-0725-N97 Recombinant Human Anti-NkG2C x Mouse Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2C Human EGFR Mouse Inquiry
KN-0725-N95 Recombinant Human Anti-NkG2C x Mouse Anti-BCMA Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2C Human BCMA Mouse Inquiry
KN-0725-N94 Recombinant Human Anti-NkG2C x Mouse Anti-CD123 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2C Human CD123 Mouse Inquiry
KN-0725-N93 Recombinant Human Anti-NkG2C x Mouse Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2C Human CD30 Mouse Inquiry
KN-0725-N90 Recombinant Human Anti-NkG2A x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2A Human GPC3 Mouse Inquiry
KN-0725-N84 Recombinant Human Anti-NkG2D x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2D Human GPC3 Mouse Inquiry
KN-0725-N78 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp46 Human GPC3 Mouse Inquiry
KN-0725-N72 Recombinant Human Anti-Nkp44 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp44 Human GPC3 Mouse Inquiry
KN-0725-N66 Recombinant Human Anti-Nkp30 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human GPC3 Mouse Inquiry
KN-0725-N62 Recombinant Human Anti-NkG2C x Mouse Anti-HER2 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human HER2 Mouse Inquiry
KN-0725-N61 Recombinant Human Anti-NkG2C x Mouse Anti-EGFR Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human EGFR Mouse Inquiry
KN-0725-N59 Recombinant Human Anti-NkG2C x Mouse Anti-BCMA Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human BCMA Mouse Inquiry
KN-0725-N58 Recombinant Human Anti-NkG2C x Mouse Anti-CD123 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human CD123 Mouse Inquiry
KN-0725-N57 Recombinant Human Anti-NkG2C x Mouse Anti-CD30 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human CD30 Mouse Inquiry
KN-0725-N54 Recombinant Human Anti-NkG2A x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2A Human GPC3 Mouse Inquiry
KN-0725-N48 Recombinant Human Anti-NkG2D x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2D Human GPC3 Mouse Inquiry
KN-0725-N42 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp46 Human GPC3 Mouse Inquiry
KN-0725-N34 Recombinant Human Anti-Nkp44 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp44 Human GPC3 Mouse Inquiry
KN-0725-N28 Recombinant Human Anti-Nkp30 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human GPC3 Mouse Inquiry
KN-0725-N24 Recombinant Human Anti-NkG2C x Mouse Anti-HER2 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human HER2 Mouse Inquiry
KN-0725-N23 Recombinant Human Anti-NkG2C x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human EGFR Mouse Inquiry
KN-0725-N21 Recombinant Human Anti-NkG2C x Mouse Anti-BCMA Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human BCMA Mouse Inquiry
KN-0725-N20 Recombinant Human Anti-NkG2C x Mouse Anti-CD123 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human CD123 Mouse Inquiry
KN-0725-N19 Recombinant Human Anti-NkG2C x Mouse Anti-CD30 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human CD30 Mouse Inquiry
KN-0725-N16 Recombinant Human Anti-NkG2A x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2A Human GPC3 Mouse Inquiry
KN-0725-N10 Recombinant Human Anti-NkG2D x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2D Human GPC3 Mouse Inquiry
KN-0725-N4 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp46 Human GPC3 Mouse Inquiry
T-BSDB-H261 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human GPC3 Human Inquiry
T-BSDB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse GPC3 Mouse Inquiry
SCIGG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human GPC3 Human Inquiry
FABVC-381 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse GPC3 llama Inquiry
BSSG-381 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (sdAb-IgG) Human sdAb-IgG CD3 Mouse GPC3 llama Inquiry
HCAB-026 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb CD3 llama GPC3 llama Inquiry
BIBD-381 Recombinant Anti-CD3 x Anti-GPC3 VHH BispecificAntibody (Bibody) Human Bibody CD3 Mouse GPC3 llama Inquiry
IGVHH-026 Recombinant Anti-CD3 x Anti-GPC3 sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb CD3 Mouse GPC3 llama Inquiry
BIVHH-026 Recombinant Anti-CD3 sdAb x Anti-GPC3 sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb CD3 llama GPC3 llama Inquiry
SCIGG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse GPC3 Mouse Inquiry
FVTIG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human GPC3 Human Inquiry
FVTIG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse GPC3 Mouse Inquiry
BSSG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human GPC3 Human Inquiry
BSSG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse GPC3 Mouse Inquiry
IGLFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human GPC3 Human Inquiry
IGLFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse GPC3 Mouse Inquiry
BSGV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse GPC3 Mouse Inquiry
BSGV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse GPC3 Mouse Inquiry
BSDG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human GPC3 Human Inquiry
BSDG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse GPC3 Mouse Inquiry
BABFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human GPC3 Human Inquiry
BABFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse GPC3 Mouse Inquiry
FABVC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human GPC3 Human Inquiry
FABVC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse GPC3 Mouse Inquiry
SCDBC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human GPC3 Human Inquiry
SCDBC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse GPC3 Mouse Inquiry
BSDBC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human GPC3 Human Inquiry
BSDBC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse GPC3 Mouse Inquiry
SCDBF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human GPC3 Human Inquiry
SCDBF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse GPC3 Mouse Inquiry
BSFVF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human GPC3 Human Inquiry
BSFVF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse GPC3 Mouse Inquiry
BSDBF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human GPC3 Human Inquiry
BSDBF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse GPC3 Mouse Inquiry
BSTF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse GPC3 Mouse Inquiry
BSTF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse GPC3 Mouse Inquiry
BSCFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse GPC3 Mouse Inquiry
BSCFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse GPC3 Mouse Inquiry
MNAB-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse GPC3 Mouse Inquiry
MNAB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse GPC3 Mouse Inquiry
BSFC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse GPC3 Mouse Inquiry
BSFC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse GPC3 Mouse Inquiry
BSCC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse GPC3 Mouse Inquiry
BSCC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse GPC3 Mouse Inquiry
BIBD-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse GPC3 Mouse Inquiry
BIBD-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse GPC3 Mouse Inquiry
FABFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human GPC3 Human Inquiry
FABFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse GPC3 Mouse Inquiry
MiniB-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Minibody) Human Minibody CD3 Human GPC3 Human Inquiry
MiniB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse GPC3 Mouse Inquiry
SCTB-H158 Recombinant Human Anti-GPC3 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human GPC3 Human Inquiry
SCDB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human GPC3 Human Inquiry
FABIG-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human GPC3 Human Inquiry
TRIB-H263 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human GPC3 Human Inquiry
BSIG-H261 Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human GPC3 Human Inquiry
CROSSAB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human GPC3 Human Inquiry
IGFV-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human GPC3 Human Inquiry
BSDB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody) Human Diabody CD3 Human GPC3 Human Inquiry
BSFAB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human GPC3 Human Inquiry
BSFV-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human GPC3 Human Inquiry
SCTB-060 Recombinant Anti-GPC3 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse GPC3 Mouse Inquiry
SCDB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse GPC3 Mouse Inquiry
FABIG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse GPC3 Mouse Inquiry
TRIB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse GPC3 Mouse Inquiry
BSIG-087 Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse GPC3 Mouse Inquiry
CROSSAB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse GPC3 Mouse Inquiry
IGFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse GPC3 Mouse Inquiry
BSDB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse GPC3 Mouse Inquiry
BSFAB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse GPC3 Mouse Inquiry
BSFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse GPC3 Mouse Inquiry

Background

Natural killer group 2 member C (NkG2C), an activating receptor on NK cells, enhances immune surveillance by recognizing stress-induced ligands on malignant cells. GPC3 (Glypican-3), a heparan sulfate proteoglycan overexpressed in hepatocellular carcinoma (HCC) and other solid tumors, drives oncogenic signaling and immune evasion. Bispecific antibodies against NkG2C and GPC3 connect NK cells to GPC3-positive tumors, allowing NkG2C-mediated activation of cytotoxic pathways while inhibiting GPC3-driven tumor growth. This bispecific format uses GPC3's tumor-specific expression to direct NK cell-mediated lysis, offering a dual mechanism: (1) GPC3 engagement impairs Wnt/YAP signaling, inhibiting proliferation, and (2) NkG2C ligation triggers perforin/granzyme release, inducing apoptosis. Such agents show promise in HCC, gastric cancer, and immunotherapy-resistant malignancies, with preclinical data supporting synergy with chemotherapy. Current clinical efforts focus on optimizing target selectivity and minimizing systemic toxicity, positioning NkG2CxGPC3 bispecifics as a transformative modality in next-generation immuno-oncology.

NKG2C/CD94 in NK cells and T cells, and GPC3 on the cell membrane. (OA Literature)Fig.1 Schematic diagram of NKG2C and GPC3.1,2

References

  1. Wang, Xiaotong et al. "Implications of NKG2A in immunity and immune-mediated diseases." Frontiers in IMMUnology vol. 13 960852. 10 Aug. 2022, doi:10.3389/fimmu.2022.960852. Distributed under Open Access license CC BY 4.0. The image was modified by extracting and using only part of the original image.
  2. Guo, Meng et al. "Glypican-3: A New Target for Diagnosis and Treatment of Hepatocellular Carcinoma." Journal of Cancer vol. 11,8 2008-2021. 3 Feb. 2020, doi:10.7150/jca.39972. Distributed under Open Access license CC BY 4.0, without modification.
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