Natural killer group 2C (NkG2C) is a C-type lectin-like receptor predominantly expressed on natural killer (NK) cells and subsets of cytotoxic T lymphocytes. It binds to HLA-E molecules presenting peptides derived from conserved regions of HLA class I leaders, facilitating immune surveillance against infected or transformed cells. NkG2C activation triggers cytotoxicity and cytokine production through adaptor protein DAP12, linking innate and adaptive immunity. Research applications span infectious diseases (e.g., cytomegalovirus control), cancer immunotherapy (targeting HLA-E+ tumors), and reproductive biology (placental NK cell function). Its role in immune memory formation and vaccine development further highlights therapeutic relevance. Tools targeting NkG2C, including monoclonal antibodies and functional assays, enable advanced studies in immune regulation and pathogenesis.
Fig.1 Schematic of NkG2C/CD94 signalings.1
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