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NkG2D & GPC3 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0725-N84 Recombinant Human Anti-NkG2D x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2D Human GPC3 Mouse Inquiry
KN-0725-N48 Recombinant Human Anti-NkG2D x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2D Human GPC3 Mouse Inquiry
KN-0725-N10 Recombinant Human Anti-NkG2D x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2D Human GPC3 Mouse Inquiry
KN-0725-N90 Recombinant Human Anti-NkG2A x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2A Human GPC3 Mouse Inquiry
KN-0725-N86 Recombinant Human Anti-NkG2D x Mouse Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2D Human HER2 Mouse Inquiry
KN-0725-N85 Recombinant Human Anti-NkG2D x Mouse Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2D Human EGFR Mouse Inquiry
KN-0725-N83 Recombinant Human Anti-NkG2D x Mouse Anti-BCMA Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2D Human BCMA Mouse Inquiry
KN-0725-N82 Recombinant Human Anti-NkG2D x Mouse Anti-CD123 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2D Human CD123 Mouse Inquiry
KN-0725-N81 Recombinant Human Anti-NkG2D x Mouse Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2D Human CD30 Mouse Inquiry
KN-0725-N78 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp46 Human GPC3 Mouse Inquiry
KN-0725-N72 Recombinant Human Anti-Nkp44 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp44 Human GPC3 Mouse Inquiry
KN-0725-N66 Recombinant Human Anti-Nkp30 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human GPC3 Mouse Inquiry
KN-0725-N60 Recombinant Human Anti-NkG2C x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human GPC3 Mouse Inquiry
KN-0725-N54 Recombinant Human Anti-NkG2A x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2A Human GPC3 Mouse Inquiry
KN-0725-N50 Recombinant Human Anti-NkG2D x Mouse Anti-HER2 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2D Human HER2 Mouse Inquiry
KN-0725-N49 Recombinant Human Anti-NkG2D x Mouse Anti-EGFR Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2D Human EGFR Mouse Inquiry
KN-0725-N47 Recombinant Human Anti-NkG2D x Mouse Anti-BCMA Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2D Human BCMA Mouse Inquiry
KN-0725-N46 Recombinant Human Anti-NkG2D x Mouse Anti-CD123 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2D Human CD123 Mouse Inquiry
KN-0725-N45 Recombinant Human Anti-NkG2D x Mouse Anti-CD30 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2D Human CD30 Mouse Inquiry
KN-0725-N42 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp46 Human GPC3 Mouse Inquiry
KN-0725-N34 Recombinant Human Anti-Nkp44 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp44 Human GPC3 Mouse Inquiry
KN-0725-N28 Recombinant Human Anti-Nkp30 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human GPC3 Mouse Inquiry
KN-0725-N22 Recombinant Human Anti-NkG2C x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human GPC3 Mouse Inquiry
KN-0725-N16 Recombinant Human Anti-NkG2A x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2A Human GPC3 Mouse Inquiry
KN-0725-N12 Recombinant Human Anti-NkG2D x Mouse Anti-HER2 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2D Human HER2 Mouse Inquiry
KN-0725-N11 Recombinant Human Anti-NkG2D x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2D Human EGFR Mouse Inquiry
KN-0725-N9 Recombinant Human Anti-NkG2D x Mouse Anti-BCMA Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2D Human BCMA Mouse Inquiry
KN-0725-N8 Recombinant Human Anti-NkG2D x Mouse Anti-CD123 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2D Human CD123 Mouse Inquiry
KN-0725-N7 Recombinant Human Anti-NkG2D x Mouse Anti-CD30 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2D Human CD30 Mouse Inquiry
KN-0725-N4 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp46 Human GPC3 Mouse Inquiry
T-BSDB-H261 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human GPC3 Human Inquiry
T-BSDB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse GPC3 Mouse Inquiry
SCIGG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human GPC3 Human Inquiry
FABVC-381 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse GPC3 llama Inquiry
BSSG-381 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (sdAb-IgG) Human sdAb-IgG CD3 Mouse GPC3 llama Inquiry
HCAB-026 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb CD3 llama GPC3 llama Inquiry
BIBD-381 Recombinant Anti-CD3 x Anti-GPC3 VHH BispecificAntibody (Bibody) Human Bibody CD3 Mouse GPC3 llama Inquiry
IGVHH-026 Recombinant Anti-CD3 x Anti-GPC3 sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb CD3 Mouse GPC3 llama Inquiry
BIVHH-026 Recombinant Anti-CD3 sdAb x Anti-GPC3 sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb CD3 llama GPC3 llama Inquiry
SCIGG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse GPC3 Mouse Inquiry
FVTIG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human GPC3 Human Inquiry
FVTIG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse GPC3 Mouse Inquiry
BSSG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human GPC3 Human Inquiry
BSSG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse GPC3 Mouse Inquiry
IGLFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human GPC3 Human Inquiry
IGLFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse GPC3 Mouse Inquiry
BSGV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse GPC3 Mouse Inquiry
BSGV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse GPC3 Mouse Inquiry
BSDG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human GPC3 Human Inquiry
BSDG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse GPC3 Mouse Inquiry
BABFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human GPC3 Human Inquiry
BABFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse GPC3 Mouse Inquiry
FABVC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human GPC3 Human Inquiry
FABVC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse GPC3 Mouse Inquiry
SCDBC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human GPC3 Human Inquiry
SCDBC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse GPC3 Mouse Inquiry
BSDBC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human GPC3 Human Inquiry
BSDBC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse GPC3 Mouse Inquiry
SCDBF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human GPC3 Human Inquiry
SCDBF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse GPC3 Mouse Inquiry
BSFVF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human GPC3 Human Inquiry
BSFVF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse GPC3 Mouse Inquiry
BSDBF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human GPC3 Human Inquiry
BSDBF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse GPC3 Mouse Inquiry
BSTF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse GPC3 Mouse Inquiry
BSTF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse GPC3 Mouse Inquiry
BSCFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse GPC3 Mouse Inquiry
BSCFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse GPC3 Mouse Inquiry
MNAB-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse GPC3 Mouse Inquiry
MNAB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse GPC3 Mouse Inquiry
BSFC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse GPC3 Mouse Inquiry
BSFC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse GPC3 Mouse Inquiry
BSCC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse GPC3 Mouse Inquiry
BSCC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse GPC3 Mouse Inquiry
BIBD-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse GPC3 Mouse Inquiry
BIBD-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse GPC3 Mouse Inquiry
FABFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human GPC3 Human Inquiry
FABFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse GPC3 Mouse Inquiry
MiniB-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Minibody) Human Minibody CD3 Human GPC3 Human Inquiry
MiniB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse GPC3 Mouse Inquiry
SCTB-H158 Recombinant Human Anti-GPC3 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human GPC3 Human Inquiry
SCDB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human GPC3 Human Inquiry
FABIG-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human GPC3 Human Inquiry
TRIB-H263 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human GPC3 Human Inquiry
BSIG-H261 Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human GPC3 Human Inquiry
CROSSAB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human GPC3 Human Inquiry
IGFV-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human GPC3 Human Inquiry
BSDB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody) Human Diabody CD3 Human GPC3 Human Inquiry
BSFAB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human GPC3 Human Inquiry
BSFV-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human GPC3 Human Inquiry
SCTB-060 Recombinant Anti-GPC3 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse GPC3 Mouse Inquiry
SCDB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse GPC3 Mouse Inquiry
FABIG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse GPC3 Mouse Inquiry
TRIB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse GPC3 Mouse Inquiry
BSIG-087 Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse GPC3 Mouse Inquiry
CROSSAB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse GPC3 Mouse Inquiry
IGFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse GPC3 Mouse Inquiry
BSDB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse GPC3 Mouse Inquiry
BSFAB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse GPC3 Mouse Inquiry
BSFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse GPC3 Mouse Inquiry

Background

Natural killer group 2D (NkG2D), an activating receptor on NK cells and T cells, recognizes stress-induced ligands on malignant or infected cells to trigger cytotoxic immune responses. Glypican-3 (GPC3), a heparan sulfate proteoglycan overexpressed in hepatocellular carcinoma and other solid tumors, serves as a tumor-specific antigen. Bispecific antibody targeting NkG2D and GPC3 synergistically bridges innate immunity and tumor specificity: NkG2D engagement activates NK cell cytotoxicity, while GPC3 binding directs immune effectors to tumor microenvironments. This dual-targeting mechanism enhances precision in eliminating cancer cells and reduces off-target effects. Such antibodies are being evaluated in preclinical and clinical studies for liver, gastric, and pancreatic cancers, offering a promising strategy for immunotherapy-resistant malignancies.

NkG2D and GPC3 associated signaling pathways in cancer. (OA Literature)Fig.1 Signaling pathways of NkG2D and GPC3 in tumor.1,2,3

References

  1. Duan, Shixin et al. "Natural killer group 2D receptor and its ligands in cancer immune escape." Molecular Cancer vol. 18,1 29. 27 Feb. 2019, doi:10.1186/s12943-019-0956-8.
  2. Zheng, Xiufeng et al. "Glypican-3: A Novel and Promising Target for the Treatment of Hepatocellular Carcinoma." Frontiers in Oncology vol. 12 824208. 16 Feb. 2022, doi:10.3389/fonc.2022.824208.
  3. Distributed under Open Access license CC BY 4.0, without modification.
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