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Nkp30 & GPC3 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0725-N102 Recombinant Human Anti-Nkp30 x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp30 Human GPC3 Mouse Inquiry
KN-0725-N66 Recombinant Human Anti-Nkp30 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human GPC3 Mouse Inquiry
KN-0725-N28 Recombinant Human Anti-Nkp30 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human GPC3 Mouse Inquiry
KN-0725-N101 Recombinant Human Anti-Nkp30 x Mouse Anti-BCMA Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp30 Human BCMA Mouse Inquiry
KN-0725-N100 Recombinant Human Anti-Nkp30 x Mouse Anti-CD123 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp30 Human CD123 Mouse Inquiry
KN-0725-N99 Recombinant Human Anti-Nkp30 x Mouse Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp30 Human CD30 Mouse Inquiry
KN-0725-N96 Recombinant Human Anti-NkG2C x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2C Human GPC3 Mouse Inquiry
KN-0725-N90 Recombinant Human Anti-NkG2A x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2A Human GPC3 Mouse Inquiry
KN-0725-N84 Recombinant Human Anti-NkG2D x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2D Human GPC3 Mouse Inquiry
KN-0725-N78 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp46 Human GPC3 Mouse Inquiry
KN-0725-N72 Recombinant Human Anti-Nkp44 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp44 Human GPC3 Mouse Inquiry
KN-0725-N68 Recombinant Human Anti-Nkp30 x Mouse Anti-HER2 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human HER2 Mouse Inquiry
KN-0725-N67 Recombinant Human Anti-Nkp30 x Mouse Anti-EGFR Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human EGFR Mouse Inquiry
KN-0725-N65 Recombinant Human Anti-Nkp30 x Mouse Anti-BCMA Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human BCMA Mouse Inquiry
KN-0725-N64 Recombinant Human Anti-Nkp30 x Mouse Anti-CD123 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human CD123 Mouse Inquiry
KN-0725-N63 Recombinant Human Anti-Nkp30 x Mouse Anti-CD30 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human CD30 Mouse Inquiry
KN-0725-N60 Recombinant Human Anti-NkG2C x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human GPC3 Mouse Inquiry
KN-0725-N54 Recombinant Human Anti-NkG2A x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2A Human GPC3 Mouse Inquiry
KN-0725-N48 Recombinant Human Anti-NkG2D x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2D Human GPC3 Mouse Inquiry
KN-0725-N42 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp46 Human GPC3 Mouse Inquiry
KN-0725-N34 Recombinant Human Anti-Nkp44 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp44 Human GPC3 Mouse Inquiry
KN-0725-N30 Recombinant Human Anti-Nkp30 x Mouse Anti-HER2 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human HER2 Mouse Inquiry
KN-0725-N29 Recombinant Human Anti-Nkp30 x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human EGFR Mouse Inquiry
KN-0725-N27 Recombinant Human Anti-Nkp30 x Mouse Anti-BCMA Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human BCMA Mouse Inquiry
KN-0725-N26 Recombinant Human Anti-Nkp30 x Mouse Anti-CD123 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human CD123 Mouse Inquiry
KN-0725-N25 Recombinant Human Anti-Nkp30 x Mouse Anti-CD30 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human CD30 Mouse Inquiry
KN-0725-N22 Recombinant Human Anti-NkG2C x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human GPC3 Mouse Inquiry
KN-0725-N16 Recombinant Human Anti-NkG2A x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2A Human GPC3 Mouse Inquiry
KN-0725-N10 Recombinant Human Anti-NkG2D x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2D Human GPC3 Mouse Inquiry
KN-0725-N4 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp46 Human GPC3 Mouse Inquiry
T-BSDB-H261 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human GPC3 Human Inquiry
T-BSDB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse GPC3 Mouse Inquiry
SCIGG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human GPC3 Human Inquiry
FABVC-381 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse GPC3 llama Inquiry
BSSG-381 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (sdAb-IgG) Human sdAb-IgG CD3 Mouse GPC3 llama Inquiry
HCAB-026 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb CD3 llama GPC3 llama Inquiry
BIBD-381 Recombinant Anti-CD3 x Anti-GPC3 VHH BispecificAntibody (Bibody) Human Bibody CD3 Mouse GPC3 llama Inquiry
IGVHH-026 Recombinant Anti-CD3 x Anti-GPC3 sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb CD3 Mouse GPC3 llama Inquiry
BIVHH-026 Recombinant Anti-CD3 sdAb x Anti-GPC3 sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb CD3 llama GPC3 llama Inquiry
SCIGG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse GPC3 Mouse Inquiry
FVTIG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human GPC3 Human Inquiry
FVTIG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse GPC3 Mouse Inquiry
BSSG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human GPC3 Human Inquiry
BSSG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse GPC3 Mouse Inquiry
IGLFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human GPC3 Human Inquiry
IGLFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse GPC3 Mouse Inquiry
BSGV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse GPC3 Mouse Inquiry
BSGV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse GPC3 Mouse Inquiry
BSDG-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human GPC3 Human Inquiry
BSDG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse GPC3 Mouse Inquiry
BABFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human GPC3 Human Inquiry
BABFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse GPC3 Mouse Inquiry
FABVC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human GPC3 Human Inquiry
FABVC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse GPC3 Mouse Inquiry
SCDBC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human GPC3 Human Inquiry
SCDBC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse GPC3 Mouse Inquiry
BSDBC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human GPC3 Human Inquiry
BSDBC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse GPC3 Mouse Inquiry
SCDBF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human GPC3 Human Inquiry
SCDBF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse GPC3 Mouse Inquiry
BSFVF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human GPC3 Human Inquiry
BSFVF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse GPC3 Mouse Inquiry
BSDBF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human GPC3 Human Inquiry
BSDBF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse GPC3 Mouse Inquiry
BSTF-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse GPC3 Mouse Inquiry
BSTF-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse GPC3 Mouse Inquiry
BSCFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse GPC3 Mouse Inquiry
BSCFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse GPC3 Mouse Inquiry
MNAB-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse GPC3 Mouse Inquiry
MNAB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse GPC3 Mouse Inquiry
BSFC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse GPC3 Mouse Inquiry
BSFC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse GPC3 Mouse Inquiry
BSCC-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse GPC3 Mouse Inquiry
BSCC-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse GPC3 Mouse Inquiry
BIBD-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse GPC3 Mouse Inquiry
BIBD-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse GPC3 Mouse Inquiry
FABFV-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human GPC3 Human Inquiry
FABFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse GPC3 Mouse Inquiry
MiniB-H263 Recombinant Human Anti-CD3 x Human Anti-GPC3 Bispecific Antibody (Minibody) Human Minibody CD3 Human GPC3 Human Inquiry
MiniB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse GPC3 Mouse Inquiry
SCTB-H158 Recombinant Human Anti-GPC3 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human GPC3 Human Inquiry
SCDB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human GPC3 Human Inquiry
FABIG-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human GPC3 Human Inquiry
TRIB-H263 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human GPC3 Human Inquiry
BSIG-H261 Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human GPC3 Human Inquiry
CROSSAB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human GPC3 Human Inquiry
IGFV-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human GPC3 Human Inquiry
BSDB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody) Human Diabody CD3 Human GPC3 Human Inquiry
BSFAB-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human GPC3 Human Inquiry
BSFV-H261 Recombinant Human Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human GPC3 Human Inquiry
SCTB-060 Recombinant Anti-GPC3 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse GPC3 Mouse Inquiry
SCDB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse GPC3 Mouse Inquiry
FABIG-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse GPC3 Mouse Inquiry
TRIB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse GPC3 Mouse Inquiry
BSIG-087 Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse GPC3 Mouse Inquiry
CROSSAB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse GPC3 Mouse Inquiry
IGFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse GPC3 Mouse Inquiry
BSDB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse GPC3 Mouse Inquiry
BSFAB-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse GPC3 Mouse Inquiry
BSFV-087 Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse GPC3 Mouse Inquiry

Background

Nkp30 is a key immune receptor constitutively expressed on NK cells, mediating cytotoxicity and cytokine release through interactions with ligands like B7-H6. It activates NK cell signaling via ITAM-associated pathways, enhancing tumor immunosurveillance against malignancies expressing its ligands. Glypican-3 (GPC3), a heparan sulfate proteoglycan overexpressed in hepatocellular carcinoma and other solid tumors, regulates cell proliferation and metastasis via Wnt signaling. Dual targeting of Nkp30 and GPC3 with a bispecific antibody bridges NK cells to GPC3-positive tumors, triggering localized cytotoxicity and immune activation. This bispecific design leverages Nkp30's sustained activation capacity and GPC3's tumor specificity, offering a precision strategy for treating refractory cancers. Applications span oncology research, particularly in enhancing NK cell-based therapies against GPC3-expressing tumors, while elucidating mechanisms of immune synapse formation.

Nkp30 and GPC3 associated signaling pathways in cancer. (OA Literature)Fig.1 Signaling pathways of Nkp30 and GPC3 in tumor.1,2,3

References

  1. Rady, Mona, and Khaled Abou-Aisha. "The antitumor immunity mediated by NK cells: the role of the NCRs." Open Cancer Immunol J 7 (2018): 7-15, doi: 10.2174/1876401001807010007.
  2. Zheng, Xiufeng et al. "Glypican-3: A Novel and Promising Target for the Treatment of Hepatocellular Carcinoma." Frontiers in Oncology vol. 12 824208. 16 Feb. 2022, doi:10.3389/fonc.2022.824208.
  3. Distributed under Open Access license CC BY 4.0, without modification.
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