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Nkp30 & HER2 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0725-N104 Recombinant Human Anti-Nkp30 x Mouse Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp30 Human HER2 Mouse Inquiry
KN-0725-N68 Recombinant Human Anti-Nkp30 x Mouse Anti-HER2 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human HER2 Mouse Inquiry
KN-0725-N30 Recombinant Human Anti-Nkp30 x Mouse Anti-HER2 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human HER2 Mouse Inquiry
IGFV-H321 Recombinant Human Anti-EGFR x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Human HER2 Human Inquiry
IGFV-H300 Recombinant Human Anti-CD64 x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 Human HER2 Human Inquiry
IGFV-H264 Recombinant Human Anti-CD3 x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human HER2 Human Inquiry
IGFV-H213 Recombinant Human Anti-CD16 x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD16 Human HER2 Human Inquiry
IGFV-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CA125 Human HER2 Human Inquiry
BSDB-H332 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody HER2 Human VEGF Human Inquiry
BSDB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER2 Human HER3 Human Inquiry
BSDB-H330 Recombinant Human Anti-HER2 x Anti-MET Bispecific Antibody (Diabody) Human Diabody HER2 Human MET Human Inquiry
BSDB-H321 Recombinant Human Anti-EGFR x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody EGFR Human HER2 Human Inquiry
BSDB-H300 Recombinant Human Anti-CD64 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CD64 Human HER2 Human Inquiry
BSDB-H264 Recombinant Human Anti-CD3 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CD3 Human HER2 Human Inquiry
BSDB-H213 Recombinant Human Anti-CD16 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CD16 Human HER2 Human Inquiry
BSDB-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CA125 Human HER2 Human Inquiry
BSFAB-H332 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Human VEGF Human Inquiry
BSFAB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Human HER3 Human Inquiry
BSFAB-H330 Recombinant Human Anti-HER2 x Anti-MET Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Human MET Human Inquiry
BSFAB-H321 Recombinant Human Anti-EGFR x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Human HER2 Human Inquiry
BSFAB-H300 Recombinant Human Anti-CD64 x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 Human HER2 Human Inquiry
BSFAB-H264 Recombinant Human Anti-CD3 x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human HER2 Human Inquiry
BSFAB-H213 Recombinant Human Anti-CD16 x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD16 Human HER2 Human Inquiry
BSFAB-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CA125 Human HER2 Human Inquiry
BSFV-H330 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Human VEGF Human Inquiry
BSFV-H329 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Human HER3 Human Inquiry
BSFV-H328 Recombinant Human Anti-HER2 x Anti-MET Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Human MET Human Inquiry
BSFV-H319 Recombinant Human Anti-EGFR x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Human HER2 Human Inquiry
BSFV-H300 Recombinant Human Anti-CD64 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 Human HER2 Human Inquiry
BSFV-H264 Recombinant Human Anti-CD3 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human HER2 Human Inquiry
BSFV-H213 Recombinant Human Anti-CD16 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD16 Human HER2 Human Inquiry
BSFV-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CA125 Human HER2 Human Inquiry
SCTB-096 Recombinant Anti-HER2 x Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD64 Mouse HER2 Mouse Inquiry
SCTB-063 Recombinant Anti-HER2 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse HER2 Mouse Inquiry
SCTB-014 Recombinant Anti-HER2 x Anti-CD16 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD16 Mouse HER2 Mouse Inquiry
SCDB-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER2 Mouse VEGF Mouse Inquiry
SCDB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER2 Mouse HER3 Mouse Inquiry
SCDB-166 Recombinant Anti-HER2 x Anti-MET Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER2 Mouse MET Mouse Inquiry
SCDB-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody EGFR Mouse HER2 Mouse Inquiry
SCDB-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD64 Mouse HER2 Mouse Inquiry
SCDB-090 Recombinant Anti-CD3 x Anti-HER2 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse HER2 Mouse Inquiry
SCDB-038 Recombinant Anti-CD16 x Anti-HER2 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD16 Mouse HER2 Mouse Inquiry
FABIG-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Mouse VEGF Mouse Inquiry
FABIG-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Mouse HER3 Mouse Inquiry
FABIG-166 Recombinant Anti-HER2 x Anti-MET Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Mouse MET Mouse Inquiry
FABIG-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Mouse HER2 Mouse Inquiry
FABIG-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD64 Mouse HER2 Mouse Inquiry
FABIG-090 Recombinant Anti-CD3 x Anti-HER2 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse HER2 Mouse Inquiry
FABIG-038 Recombinant Anti-CD16 x Anti-HER2 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD16 Mouse HER2 Mouse Inquiry
FABIG-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Fab-IgG) Human Fab-IgG CA125 Mouse HER2 Mouse Inquiry
TRIB-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Mouse VEGF Mouse Inquiry
TRIB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Mouse HER3 Mouse Inquiry
TRIB-166 Recombinant Anti-HER2 x Anti-MET Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Mouse MET Mouse Inquiry
TRIB-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse HER2 Mouse Inquiry
TRIB-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD64 Mouse HER2 Mouse Inquiry
TRIB-090 Recombinant Anti-CD3 x Anti-HER2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse HER2 Mouse Inquiry
TRIB-038 Recombinant Anti-CD16 x Anti-HER2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD16 Mouse HER2 Mouse Inquiry
TRIB-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CA125 Mouse HER2 Mouse Inquiry
BSIG-168 Anti-HER2 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Mouse VEGF Mouse Inquiry
BSIG-167 Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Mouse HER3 Mouse Inquiry
BSIG-166 Anti-HER2 x Anti-MET Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Mouse MET Mouse Inquiry
BSIG-155 Anti-EGFR x Anti-HER2 Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse HER2 Mouse Inquiry
BSIG-128 Anti-CD64 x Anti-HER2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD64 Mouse HER2 Mouse Inquiry
BSIG-090 Anti-CD3 x Anti-HER2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse HER2 Mouse Inquiry
BSIG-038 Anti-CD16 x Anti-HER2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD16 Mouse HER2 Mouse Inquiry
BSIG-025 Anti-CA125 x Anti-HER2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CA125 Mouse HER2 Mouse Inquiry
CROSSAB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER2 Mouse HER3 Mouse Inquiry
CROSSAB-166 Recombinant Anti-HER2 x Anti-MET Bispecific Antibody (CrossMab) Human CrossMab HER2 Mouse MET Mouse Inquiry
CROSSAB-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (CrossMab) Human CrossMab EGFR Mouse HER2 Mouse Inquiry
CROSSAB-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (CrossMab) Human CrossMab CD64 Mouse HER2 Mouse Inquiry
CROSSAB-090 Recombinant Anti-CD3 x Anti-HER2 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse HER2 Mouse Inquiry
CROSSAB-038 Recombinant Anti-CD16 x Anti-HER2 Bispecific Antibody (CrossMab) Human CrossMab CD16 Mouse HER2 Mouse Inquiry
CROSSAB-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (CrossMab) Human CrossMab CA125 Mouse HER2 Mouse Inquiry
IGFV-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Mouse VEGF Mouse Inquiry
IGFV-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Mouse HER3 Mouse Inquiry
IGFV-166 Recombinant Anti-HER2 x Anti-MET Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Mouse MET Mouse Inquiry
IGFV-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse HER2 Mouse Inquiry
IGFV-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 Mouse HER2 Mouse Inquiry
IGFV-090 Recombinant Anti-CD3 x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse HER2 Mouse Inquiry
IGFV-038 Recombinant Anti-CD16 x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD16 Mouse HER2 Mouse Inquiry
BSDB-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody HER2 Mouse VEGF Mouse Inquiry
BSDB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER2 Mouse HER3 Mouse Inquiry
BSDB-166 Recombinant Anti-HER2 x Anti-MET Bispecific Antibody (Diabody) Human Diabody HER2 Mouse MET Mouse Inquiry
BSDB-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody EGFR Mouse HER2 Mouse Inquiry
BSDB-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CD64 Mouse HER2 Mouse Inquiry
BSDB-090 Recombinant Anti-CD3 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse HER2 Mouse Inquiry
BSDB-038 Recombinant Anti-CD16 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CD16 Mouse HER2 Mouse Inquiry
BSDB-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CA125 Mouse HER2 Mouse Inquiry
BSFAB-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Mouse VEGF Mouse Inquiry
BSFAB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Mouse HER3 Mouse Inquiry
BSFAB-166 Recombinant Anti-HER2 x Anti-MET Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Mouse MET Mouse Inquiry
BSFAB-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse HER2 Mouse Inquiry
BSFAB-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 Mouse HER2 Mouse Inquiry
BSFAB-090 Recombinant Anti-CD3 x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse HER2 Mouse Inquiry
BSFAB-038 Recombinant Anti-CD16 x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD16 Mouse HER2 Mouse Inquiry
BSFV-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Mouse VEGF Mouse Inquiry
BSFV-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Mouse HER3 Mouse Inquiry
BSFV-166 Recombinant Anti-HER2 x Anti-MET Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Mouse MET Mouse Inquiry
BSFV-155 Recombinant Anti-EGFR x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse HER2 Mouse Inquiry
BSFV-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 Mouse HER2 Mouse Inquiry
BSFV-090 Recombinant Anti-CD3 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse HER2 Mouse Inquiry
BSFV-038 Recombinant Anti-CD16 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD16 Mouse HER2 Mouse Inquiry
BSFV-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CA125 Mouse HER2 Mouse Inquiry

Background

Nkp30, a key activating receptor on natural killer (NK) cells, regulates cytotoxic activity against tumor cells by interacting with tumor-derived ligands. HER2, a tyrosine kinase receptor overexpressed in malignancies like breast and gastric cancers, drives oncogenic signaling and cell proliferation. Bispecific antibodies (bsAbs) co-targeting Nkp30 and HER2 bridge NK cells with HER2-positive cancer cells, enhancing antibody-dependent cellular cytotoxicity (ADCC) via NK cell activation and HER2 pathway inhibition. These bsAbs leverage dual mechanisms: (1) redirecting NK cell-mediated tumor lysis by engaging Nkp30, and (2) blocking HER2 dimerization to suppress oncogenic signaling. Such bsAbs hold therapeutic potential in HER2-driven cancers, particularly for resistant or metastatic cases requiring immune activation. Research extends to combinatorial immunotherapy, biomarker-driven patient stratification, and NK cell exhaustion modulation.

Downstream signaling pathway of Nkp30 and HER2. (OA Literature)Fig.1 Signaling downstream of Nkp30 and HER2.1,2

References

  1. Chen, Yingying et al. "Research Progress on NK Cell Receptors and Their Signaling Pathways." Mediators of Inflammation vol. 2020 6437057. 24 Jul. 2020, doi:10.1155/2020/6437057. Distributed under Open Access license CC BY 4.0, without modification.
  2. Larionov, Alexey A. "Current Therapies for Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Patients." Frontiers in Oncology vol. 8 89. 3 Apr. 2018, doi:10.3389/fonc.2018.00089. Distributed under Open Access license CC BY 4.0. The image was modified by extracting and using only part of the original image.
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