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Nkp44 & CD30 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0725-N105 Recombinant Human Anti-Nkp44 x Mouse Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp44 Human CD30 Mouse Inquiry
KN-0725-N69 Recombinant Human Anti-Nkp44 x Mouse Anti-CD30 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp44 Human CD30 Mouse Inquiry
KN-0725-N31 Recombinant Human Anti-Nkp44 x Mouse Anti-CD30 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp44 Human CD30 Mouse Inquiry
BIBD-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Bibody) Human Bibody CD30 Mouse CD64 Mouse Inquiry
BIBD-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse CD30 Mouse Inquiry
BIBD-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Bibody) Human Bibody CD28 Mouse CD30 Mouse Inquiry
BIBD-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Bibody) Human Bibody CD16 Mouse CD30 Mouse Inquiry
FABFV-H286 Recombinant Human Anti-CD30 x Human Anti-CD64 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD30 Human CD64 Human Inquiry
FABFV-H241 Recombinant Human Anti-CD3 x Human Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human CD30 Human Inquiry
FABFV-H231 Recombinant Human Anti-CD28 x Human Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Human CD30 Human Inquiry
FABFV-H211 Recombinant Human Anti-CD16 x Human Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD16 Human CD30 Human Inquiry
FABFV-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD30 Mouse CD64 Mouse Inquiry
FABFV-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse CD30 Mouse Inquiry
FABFV-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Mouse CD30 Mouse Inquiry
FABFV-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD16 Mouse CD30 Mouse Inquiry
MiniB-H286 Recombinant Human Anti-CD30 x Human Anti-CD64 Bispecific Antibody (Minibody) Human Minibody CD30 Human CD64 Human Inquiry
MiniB-H241 Recombinant Human Anti-CD3 x Human Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD3 Human CD30 Human Inquiry
MiniB-H231 Recombinant Human Anti-CD28 x Human Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD28 Human CD30 Human Inquiry
MiniB-H211 Recombinant Human Anti-CD16 x Human Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD16 Human CD30 Human Inquiry
MiniB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Minibody) Human Minibody CD30 Mouse CD64 Mouse Inquiry
MiniB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse CD30 Mouse Inquiry
MiniB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD28 Mouse CD30 Mouse Inquiry
MiniB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD16 Mouse CD30 Mouse Inquiry
SCTB-H179 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD30 Human CD64 Human Inquiry
SCTB-H135 Recombinant Human Anti-CD30 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human CD30 Human Inquiry
SCTB-H126 Recombinant Human Anti-CD30 x Human Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Human CD30 Human Inquiry
SCTB-H111 Recombinant Human Anti-CD30 x Human Anti-CD16 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD16 Human CD30 Human Inquiry
SCDB-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD30 Human CD64 Human Inquiry
SCDB-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human CD30 Human Inquiry
SCDB-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Human CD30 Human Inquiry
SCDB-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD16 Human CD30 Human Inquiry
FABIG-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD30 Human CD64 Human Inquiry
FABIG-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human CD30 Human Inquiry
FABIG-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Human CD30 Human Inquiry
FABIG-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD16 Human CD30 Human Inquiry
TRIB-H286 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD30 Human CD64 Human Inquiry
TRIB-H241 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human CD30 Human Inquiry
TRIB-H231 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Human CD30 Human Inquiry
TRIB-H211 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD16 Human CD30 Human Inquiry
BSIG-H284 Human Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD30 Human CD64 Human Inquiry
BSIG-H239 Human Anti-CD3 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human CD30 Human Inquiry
BSIG-H229 Human Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Human CD30 Human Inquiry
BSIG-H209 Human Anti-CD16 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD16 Human CD30 Human Inquiry
CROSSAB-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD30 Human CD64 Human Inquiry
CROSSAB-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human CD30 Human Inquiry
CROSSAB-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD28 Human CD30 Human Inquiry
CROSSAB-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD16 Human CD30 Human Inquiry
IGFV-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD30 Human CD64 Human Inquiry
IGFV-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human CD30 Human Inquiry
IGFV-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Human CD30 Human Inquiry
IGFV-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD16 Human CD30 Human Inquiry
BSDB-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD30 Human CD64 Human Inquiry
BSDB-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD3 Human CD30 Human Inquiry
BSDB-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD28 Human CD30 Human Inquiry
BSDB-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD16 Human CD30 Human Inquiry
BSFAB-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD30 Human CD64 Human Inquiry
BSFAB-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human CD30 Human Inquiry
BSFAB-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Human CD30 Human Inquiry
BSFAB-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD16 Human CD30 Human Inquiry
BSFV-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD30 Human CD64 Human Inquiry
BSFV-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human CD30 Human Inquiry
BSFV-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Human CD30 Human Inquiry
BSFV-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD16 Human CD30 Human Inquiry
SCTB-083 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD30 Mouse CD64 Mouse Inquiry
SCTB-037 Recombinant Anti-CD30 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse CD30 Mouse Inquiry
SCTB-027 Recombinant Anti-CD30 x Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Mouse CD30 Mouse Inquiry
SCTB-011 Recombinant Anti-CD30 x Anti-CD16 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD16 Mouse CD30 Mouse Inquiry
SCDB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD30 Mouse CD64 Mouse Inquiry
SCDB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse CD30 Mouse Inquiry
SCDB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Mouse CD30 Mouse Inquiry
SCDB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD16 Mouse CD30 Mouse Inquiry
FABIG-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD30 Mouse CD64 Mouse Inquiry
FABIG-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse CD30 Mouse Inquiry
FABIG-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse CD30 Mouse Inquiry
FABIG-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD16 Mouse CD30 Mouse Inquiry
TRIB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD30 Mouse CD64 Mouse Inquiry
TRIB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse CD30 Mouse Inquiry
TRIB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse CD30 Mouse Inquiry
TRIB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD16 Mouse CD30 Mouse Inquiry
BSIG-110 Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD30 Mouse CD64 Mouse Inquiry
BSIG-065 Anti-CD3 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse CD30 Mouse Inquiry
BSIG-055 Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse CD30 Mouse Inquiry
BSIG-034 Anti-CD16 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD16 Mouse CD30 Mouse Inquiry
CROSSAB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD30 Mouse CD64 Mouse Inquiry
CROSSAB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse CD30 Mouse Inquiry
CROSSAB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse CD30 Mouse Inquiry
CROSSAB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD16 Mouse CD30 Mouse Inquiry
IGFV-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD30 Mouse CD64 Mouse Inquiry
IGFV-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse CD30 Mouse Inquiry
IGFV-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse CD30 Mouse Inquiry
IGFV-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD16 Mouse CD30 Mouse Inquiry
BSDB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD30 Mouse CD64 Mouse Inquiry
BSDB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse CD30 Mouse Inquiry
BSDB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse CD30 Mouse Inquiry
BSDB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD16 Mouse CD30 Mouse Inquiry
BSFAB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD30 Mouse CD64 Mouse Inquiry
BSFAB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse CD30 Mouse Inquiry
BSFAB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse CD30 Mouse Inquiry
BSFAB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD16 Mouse CD30 Mouse Inquiry
BSFV-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD30 Mouse CD64 Mouse Inquiry
BSFV-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse CD30 Mouse Inquiry
BSFV-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse CD30 Mouse Inquiry
BSFV-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD16 Mouse CD30 Mouse Inquiry

Background

Nkp44 (CD336) is selectively expressed on activated NK cells and subsets of T lymphocytes. It associates with DAP12 to activate NK cell cytotoxicity and cytokine production, playing pivotal roles in antiviral defense and tumor immune surveillance. Emerging studies reveal its interaction with HLA-DP molecules, expanding its therapeutic potential in autoimmune and inflammatory diseases. CD30 (TNFRSF8), a tumor necrosis factor receptor superfamily member, is overexpressed in Hodgkin lymphoma and select malignancies, serving as a validated target for antibody-based therapies. Bispecific antibodies engaging Nkp44 and CD30 offer a novel approach to redirect NK cell activity against CD30-positive malignancies. By simultaneously binding Nkp44 on NK cells and CD30 on tumor cells, these bispecific constructs enhance immune synapse formation, promoting precise tumor lysis via antibody-dependent cellular cytotoxicity and cytokine release. Such strategies are particularly promising in hematologic oncology, infectious disease models, and immune dysregulation disorders, leveraging synergistic activation of innate immunity with tumor-specific targeting.

Signaling downstream pathways of Nkp44 and CD30 and their targeting. (OA Literature)Fig.1 Signaling downstream of Nkp44 and CD30.1,2,3

References

  1. Rady, Mona, and Khaled Abou-Aisha. "The antitumor immunity mediated by NK cells: the role of the NCRs." Open Cancer Immunol J 7 (2018): 7-15, doi: 10.2174/1876401001807010007.
  2. van der Weyden, C A et al. "Understanding CD30 biology and therapeutic targeting: a historical perspective providing insight into future directions." Blood Cancer Journal vol. 7,9 e603. 8 Sep. 2017, doi:10.1038/bcj.2017.85.
  3. Distributed under Open Access license CC BY 4.0, without modification.
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