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Nkp46 & CD123 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0725-N76 Recombinant Human Anti-Nkp46 x Mouse Anti-CD123 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp46 Human CD123 Mouse Inquiry
KN-0725-N40 Recombinant Human Anti-Nkp46 x Mouse Anti-CD123 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp46 Human CD123 Mouse Inquiry
KN-0725-N2 Recombinant Human Anti-Nkp46 x Mouse Anti-CD123 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp46 Human CD123 Mouse Inquiry
KN-0725-N100 Recombinant Human Anti-Nkp30 x Mouse Anti-CD123 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp30 Human CD123 Mouse Inquiry
KN-0725-N94 Recombinant Human Anti-NkG2C x Mouse Anti-CD123 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2C Human CD123 Mouse Inquiry
KN-0725-N88 Recombinant Human Anti-NkG2A x Mouse Anti-CD123 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2A Human CD123 Mouse Inquiry
KN-0725-N82 Recombinant Human Anti-NkG2D x Mouse Anti-CD123 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2D Human CD123 Mouse Inquiry
KN-0725-N80 Recombinant Human Anti-Nkp46 x Mouse Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp46 Human HER2 Mouse Inquiry
KN-0725-N79 Recombinant Human Anti-Nkp46 x Mouse Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp46 Human EGFR Mouse Inquiry
KN-0725-N78 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp46 Human GPC3 Mouse Inquiry
KN-0725-N77 Recombinant Human Anti-Nkp46 x Mouse Anti-BCMA Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp46 Human BCMA Mouse Inquiry
KN-0725-N75 Recombinant Human Anti-Nkp46 x Mouse Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab Nkp46 Human CD30 Mouse Inquiry
KN-0725-N70 Recombinant Human Anti-Nkp44 x Mouse Anti-CD123 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp44 Human CD123 Mouse Inquiry
KN-0725-N64 Recombinant Human Anti-Nkp30 x Mouse Anti-CD123 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp30 Human CD123 Mouse Inquiry
KN-0725-N58 Recombinant Human Anti-NkG2C x Mouse Anti-CD123 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2C Human CD123 Mouse Inquiry
KN-0725-N52 Recombinant Human Anti-NkG2A x Mouse Anti-CD123 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2A Human CD123 Mouse Inquiry
KN-0725-N46 Recombinant Human Anti-NkG2D x Mouse Anti-CD123 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2D Human CD123 Mouse Inquiry
KN-0725-N44 Recombinant Human Anti-Nkp46 x Mouse Anti-HER2 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp46 Human HER2 Mouse Inquiry
KN-0725-N43 Recombinant Human Anti-Nkp46 x Mouse Anti-EGFR Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp46 Human EGFR Mouse Inquiry
KN-0725-N42 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp46 Human GPC3 Mouse Inquiry
KN-0725-N41 Recombinant Human Anti-Nkp46 x Mouse Anti-BCMA Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp46 Human BCMA Mouse Inquiry
KN-0725-N39 Recombinant Human Anti-Nkp46 x Mouse Anti-CD30 Bispecific Antibody (scFv-Fc) Human scFv-Fc Nkp46 Human CD30 Mouse Inquiry
KN-0725-N32 Recombinant Human Anti-Nkp44 x Mouse Anti-CD123 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp44 Human CD123 Mouse Inquiry
KN-0725-N26 Recombinant Human Anti-Nkp30 x Mouse Anti-CD123 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp30 Human CD123 Mouse Inquiry
KN-0725-N20 Recombinant Human Anti-NkG2C x Mouse Anti-CD123 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2C Human CD123 Mouse Inquiry
KN-0725-N14 Recombinant Human Anti-NkG2A x Mouse Anti-CD123 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2A Human CD123 Mouse Inquiry
KN-0725-N8 Recombinant Human Anti-NkG2D x Mouse Anti-CD123 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2D Human CD123 Mouse Inquiry
KN-0725-N6 Recombinant Human Anti-Nkp46 x Mouse Anti-HER2 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp46 Human HER2 Mouse Inquiry
KN-0725-N5 Recombinant Human Anti-Nkp46 x Mouse Anti-EGFR Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp46 Human EGFR Mouse Inquiry
KN-0725-N4 Recombinant Human Anti-Nkp46 x Mouse Anti-GPC3 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp46 Human GPC3 Mouse Inquiry
KN-0725-N3 Recombinant Human Anti-Nkp46 x Mouse Anti-BCMA Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp46 Human BCMA Mouse Inquiry
KN-0725-N1 Recombinant Human Anti-Nkp46 x Mouse Anti-CD30 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv Nkp46 Human CD30 Mouse Inquiry
T-BSDB-H205 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD123 Human CD3 Human Inquiry
T-BSDB-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD123 Mouse CD3 Mouse Inquiry
SCIGG-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (scIgG) Human Single chain IgGs CD123 Human CD3 Human Inquiry
SCIGG-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (scIgG) Human Single chain IgGs CD123 Mouse CD3 Mouse Inquiry
FVTIG-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD123 Human CD3 Human Inquiry
FVTIG-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD123 Mouse CD3 Mouse Inquiry
BSSG-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD123 Human CD3 Human Inquiry
BSSG-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD123 Mouse CD3 Mouse Inquiry
IGLFV-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD123 Human CD3 Human Inquiry
IGLFV-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD123 Mouse CD3 Mouse Inquiry
BSGV-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD123 Human CD3 Human Inquiry
BSGV-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD123 Mouse CD3 Mouse Inquiry
BSDG-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD123 Human CD3 Human Inquiry
BSDG-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD123 Mouse CD3 Mouse Inquiry
BABFV-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD123 Human CD3 Human Inquiry
BABFV-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD123 Mouse CD3 Mouse Inquiry
FABVC-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD123 Human CD3 Human Inquiry
FABVC-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD123 Mouse CD3 Mouse Inquiry
SCDBC-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD123 Human CD3 Human Inquiry
SCDBC-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD123 Mouse CD3 Mouse Inquiry
BSDBC-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD123 Human CD3 Human Inquiry
BSDBC-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD123 Mouse CD3 Mouse Inquiry
SCDBF-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD123 Human CD3 Human Inquiry
SCDBF-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD123 Mouse CD3 Mouse Inquiry
BSFVF-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD123 Human CD3 Human Inquiry
BSFVF-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD123 Mouse CD3 Mouse Inquiry
BSDBF-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD123 Human CD3 Human Inquiry
BSDBF-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD123 Mouse CD3 Mouse Inquiry
BSTF-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD123 Human CD3 Human Inquiry
BSTF-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD123 Mouse CD3 Mouse Inquiry
BSCFV-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD123 Human CD3 Human Inquiry
BSCFV-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD123 Mouse CD3 Mouse Inquiry
MNAB-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Miniantibody) Human Miniantibody CD123 Human CD3 Human Inquiry
MNAB-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Miniantibody) Human Miniantibody CD123 Mouse CD3 Mouse Inquiry
BSFC-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD123 Human CD3 Human Inquiry
BSFC-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD123 Mouse CD3 Mouse Inquiry
BSCC-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD123 Human CD3 Human Inquiry
BSCC-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD123 Mouse CD3 Mouse Inquiry
BIBD-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Bibody) Human Bibody CD123 Human CD3 Human Inquiry
BIBD-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Bibody) Human Bibody CD123 Mouse CD3 Mouse Inquiry
FABFV-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD123 Human CD3 Human Inquiry
FABFV-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD123 Mouse CD3 Mouse Inquiry
MiniB-H207 Recombinant Human Anti-CD123 x Human Anti-CD3 Bispecific Antibody (Minibody) Human Minibody CD123 Human CD3 Human Inquiry
MiniB-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Minibody) Human Minibody CD123 Mouse CD3 Mouse Inquiry
SCTB-H196 Recombinant Human Anti-CD33 x Anti-CD16 x CD123 Trispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD33 Human CD16 Human Inquiry
SCTB-H109 Recombinant Human Anti-CD123 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD123 Human CD3 Human Inquiry
SCDB-H205 Recombinant Human Anti-CD123 x Anti-CD3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD123 Human CD3 Human Inquiry
FABIG-H205 Recombinant Human Anti-CD123 x Anti-CD3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD123 Human CD3 Human Inquiry
TRIB-H353 Recombinant Human Anti-CD16 x Anti-CD33 x Anti-CD123 Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD16 Human CD33 Human Inquiry
TRIB-H207 Recombinant Human Anti-CD123 x Anti-CD3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD123 Human CD3 Human Inquiry
BSIG-H205 Human Anti-CD123 x Anti-CD3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD123 Human CD3 Human Inquiry
CROSSAB-H205 Recombinant Human Anti-CD123 x Anti-CD3 Bispecific Antibody (CrossMab) Human CrossMab CD123 Human CD3 Human Inquiry
IGFV-H205 Recombinant Human Anti-CD123 x Anti-CD3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD123 Human CD3 Human Inquiry
BSDB-H205 Recombinant Human Anti-CD123 x Anti-CD3 Bispecific Antibody (Diabody) Human Diabody CD123 Human CD3 Human Inquiry
BSFAB-H205 Recombinant Human Anti-CD123 x Anti-CD3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD123 Human CD3 Human Inquiry
BSFV-H205 Recombinant Human Anti-CD123 x Anti-CD3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD123 Human CD3 Human Inquiry
SCTB-104 Recombinant Anti-CD33 x Anti-CD16 x CD123 Trispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD33 Mouse CD16 Mouse Inquiry
SCTB-009 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD123 Mouse CD3 Mouse Inquiry
SCDB-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD123 Mouse CD3 Mouse Inquiry
FABIG-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD123 Mouse CD3 Mouse Inquiry
TRIB-192 Recombinant Anti-CD16 x Anti-CD33 x Anti-CD123 Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD16 Mouse CD33 Mouse Inquiry
TRIB-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD123 Mouse CD3 Mouse Inquiry
BSIG-030 Anti-CD123 x Anti-CD3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD123 Mouse CD3 Mouse Inquiry
CROSSAB-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (CrossMab) Human CrossMab CD123 Mouse CD3 Mouse Inquiry
IGFV-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD123 Mouse CD3 Mouse Inquiry
BSDB-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Diabody) Human Diabody CD123 Mouse CD3 Mouse Inquiry
BSFAB-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD123 Mouse CD3 Mouse Inquiry
BSFV-030 Recombinant Anti-CD123 x Anti-CD3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD123 Mouse CD3 Mouse Inquiry

Background

Nkp46, an immunoglobulin superfamily receptor expressed on activated NK cells, mediates cytotoxicity against malignant cells by engaging stress-induced ligands on tumors. Interleukin-3 receptor alpha subunit (CD123), overexpressed on leukemic stem cells and acute myeloid leukemia (AML) blasts, drives proliferation and survival. Bispecific antibodies co-targeting Nkp46 and CD123 bridge NK cells and CD123⁺ malignancies, enabling directed NK cell activation and tumor elimination. These agents exploit Nkp46's role in immune synapse formation and CD123's tumor specificity, enhancing cytotoxicity while minimizing off-target effects. Preclinical studies demonstrate that such bispecific formats activate NK cells selectively in the presence of tumor cells, induce potent AML cell lysis, and exhibit favorable safety profiles. Their modular design enables applications in hematologic malignancies (e.g., AML) and CD123⁺ solid tumors. Emerging platforms optimize binding valency and Fc engineering to maximize efficacy across diverse cancer models.

Pathways and ligands involved in Nkp46 and CD123. (OA Literature)Fig.1 Mechanism of action of Nkp46 and CD123.1,2

References

  1. Pazina, Tatiana et al. "Regulation of the Functions of Natural Cytotoxicity Receptors by Interactions with Diverse Ligands and Alterations in Splice Variant Expression." Frontiers in immunology vol. 8 369. 30 Mar. 2017, doi:10.3389/fimmu.2017.00369. Distributed under Open Access license CC BY 4.0, without modification.
  2. Galati, Domenico et al. "Immunotherapies Targeting CD123 and CD303: A New Frontier in Treating Blastic Plasmacytoid Dendritic Cell Neoplasm." International Journal of Molecular Sciences vol. 26,6 2732. 18 Mar. 2025, doi:10.3390/ijms26062732. Distributed under Open Access license CC BY 4.0. The image was modified by extracting and using only part of the original image.
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