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PDGFR1 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H347 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Tandem Diabody) Human Tandem Diabody PDGFR1 Human VEGF Human Inquiry
T-BSDB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem Diabody) Human Tandem Diabody PDGFR1 Mouse VEGF Mouse Inquiry
SCIGG-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scIgG) Human Single chain IgGs PDGFR1 Human VEGF Human Inquiry
SCIGG-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scIgG) Human Single chain IgGs PDGFR1 Mouse VEGF Mouse Inquiry
FVTIG-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scFv4-Ig) Human scFv4-Ig PDGFR1 Human VEGF Human Inquiry
FVTIG-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv4-Ig) Human scFv4-Ig PDGFR1 Mouse VEGF Mouse Inquiry
BSSG-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scFv-IgG) Human scFv-IgG PDGFR1 Human VEGF Human Inquiry
BSSG-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv-IgG) Human scFv-IgG PDGFR1 Mouse VEGF Mouse Inquiry
IGLFV-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv PDGFR1 Human VEGF Human Inquiry
IGLFV-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv PDGFR1 Mouse VEGF Mouse Inquiry
BSGV-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (IgG-Fv) Human IgG-Fv PDGFR1 Mouse VEGF Mouse Inquiry
BSGV-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG-Fv) Human IgG-Fv PDGFR1 Mouse VEGF Mouse Inquiry
BSDG-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Fv-IgG) Human Fv-IgG PDGFR1 Human VEGF Human Inquiry
BSDG-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fv-IgG) Human Fv-IgG PDGFR1 Mouse VEGF Mouse Inquiry
BABFV-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 PDGFR1 Human VEGF Human Inquiry
BABFV-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 PDGFR1 Mouse VEGF Mouse Inquiry
FABVC-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc PDGFR1 Human VEGF Human Inquiry
FABVC-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc PDGFR1 Mouse VEGF Mouse Inquiry
SCDBC-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 PDGFR1 Human VEGF Human Inquiry
SCDBC-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 PDGFR1 Mouse VEGF Mouse Inquiry
BSDBC-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 PDGFR1 Human VEGF Human Inquiry
BSDBC-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 PDGFR1 Mouse VEGF Mouse Inquiry
SCDBF-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc PDGFR1 Human VEGF Human Inquiry
SCDBF-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc PDGFR1 Mouse VEGF Mouse Inquiry
BSFVF-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc PDGFR1 Human VEGF Human Inquiry
BSFVF-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc PDGFR1 Mouse VEGF Mouse Inquiry
BSDBF-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Diabody-Fc) Human Diabody-Fc PDGFR1 Human VEGF Human Inquiry
BSDBF-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Diabody-Fc) Human Diabody-Fc PDGFR1 Mouse VEGF Mouse Inquiry
BSTF-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv PDGFR1 Mouse VEGF Mouse Inquiry
BSTF-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv PDGFR1 Mouse VEGF Mouse Inquiry
BSCFV-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scFv-Fc) Human scFv-Fc PDGFR1 Mouse VEGF Mouse Inquiry
BSCFV-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv-Fc) Human scFv-Fc PDGFR1 Mouse VEGF Mouse Inquiry
MNAB-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Miniantibody) Human Miniantibody PDGFR1 Mouse VEGF Mouse Inquiry
MNAB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Miniantibody) Human Miniantibody PDGFR1 Mouse VEGF Mouse Inquiry
BSFC-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scFv-CH3) Human scFv-CH3 PDGFR1 Mouse VEGF Mouse Inquiry
BSFC-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv-CH3) Human scFv-CH3 PDGFR1 Mouse VEGF Mouse Inquiry
BSCC-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL PDGFR1 Mouse VEGF Mouse Inquiry
BSCC-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL PDGFR1 Mouse VEGF Mouse Inquiry
BIBD-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Bibody) Human Bibody PDGFR1 Mouse VEGF Mouse Inquiry
BIBD-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Bibody) Human Bibody PDGFR1 Mouse VEGF Mouse Inquiry
FABFV-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Fab-Fv) Human Fab-Fv PDGFR1 Human VEGF Human Inquiry
FABFV-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-Fv) Human Fab-Fv PDGFR1 Mouse VEGF Mouse Inquiry
MiniB-H349 Recombinant Human Anti-PDGFR1 x Human Anti-VEGF Bispecific Antibody (Minibody) Human Minibody PDGFR1 Human VEGF Human Inquiry
MiniB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Minibody) Human Minibody PDGFR1 Mouse VEGF Mouse Inquiry
SCDB-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody PDGFR1 Human VEGF Human Inquiry
FABIG-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG PDGFR1 Human VEGF Human Inquiry
TRIB-H349 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv PDGFR1 Human VEGF Human Inquiry
BSIG-H347 Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG PDGFR1 Human VEGF Human Inquiry
CROSSAB-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab PDGFR1 Human VEGF Human Inquiry
IGFV-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv PDGFR1 Human VEGF Human Inquiry
BSDB-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody PDGFR1 Human VEGF Human Inquiry
BSFAB-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab PDGFR1 Human VEGF Human Inquiry
BSFV-H346 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv PDGFR1 Human VEGF Human Inquiry
SCDB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody PDGFR1 Mouse VEGF Mouse Inquiry
FABIG-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG PDGFR1 Mouse VEGF Mouse Inquiry
TRIB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv PDGFR1 Mouse VEGF Mouse Inquiry
BSIG-186 Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG PDGFR1 Mouse VEGF Mouse Inquiry
CROSSAB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab PDGFR1 Mouse VEGF Mouse Inquiry
IGFV-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv PDGFR1 Mouse VEGF Mouse Inquiry
BSDB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody PDGFR1 Mouse VEGF Mouse Inquiry
BSFAB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab PDGFR1 Mouse VEGF Mouse Inquiry
BSFV-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv PDGFR1 Mouse VEGF Mouse Inquiry

Background

Fig 1. Structure of the PDGF-B: PDGFRβ complex. (Shim, et al., 2010)Fig.1 Structure of the PDGF-B: PDGFRβ complex.1

Platelet-derived growth factor receptor 1 (PDGFR1), also known as PDGFRβ, is a receptor protein found on the surface of cells. It works by binding to its ligands, platelet-derived growth factors (PDGFs). PDGFR1 activation triggers a cascade of intracellular signaling events that regulate a variety of cellular processes, such as cell survival, migration, and tissue repair. PDGFR1 is involved in embryonic development, angiogenesis, wound healing, and tissue regeneration. Dysregulation or overexpression of PDGFR1 is associated with various diseases, including certain types of cancer, fibrotic disorders, and vascular diseases. Targeting PDGFR1 can be achieved through the development of monoclonal antibodies or small molecule inhibitors, and it has the potential to improve the efficacy of other cancer treatments such as radiation or chemotherapy therapy. The application fields for targeting PDGFR1 include cancer treatment, fibrotic disorders, and vascular diseases.

Reference

  1. Shim, Ann Hye-Ryong, et al. “Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.” Proceedings of the National Academy of Sciences of the United States of America vol. 107,25 (2010): 11307-12.
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