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PDGFR2 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H348 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody PDGFR2 Human VEGFR2 Human Inquiry
T-BSDB-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody PDGFR2 Mouse VEGFR2 Mouse Inquiry
SCIGG-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scIgG) Human Single chain IgGs PDGFR2 Human VEGFR2 Human Inquiry
SCIGG-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scIgG) Human Single chain IgGs PDGFR2 Mouse VEGFR2 Mouse Inquiry
FVTIG-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig PDGFR2 Human VEGFR2 Human Inquiry
FVTIG-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSSG-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scFv-IgG) Human scFv-IgG PDGFR2 Human VEGFR2 Human Inquiry
BSSG-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scFv-IgG) Human scFv-IgG PDGFR2 Mouse VEGFR2 Mouse Inquiry
IGLFV-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv PDGFR2 Human VEGFR2 Human Inquiry
IGLFV-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSGV-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (IgG-Fv) Human IgG-Fv PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSGV-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (IgG-Fv) Human IgG-Fv PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSDG-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Fv-IgG) Human Fv-IgG PDGFR2 Human VEGFR2 Human Inquiry
BSDG-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Fv-IgG) Human Fv-IgG PDGFR2 Mouse VEGFR2 Mouse Inquiry
BABFV-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 PDGFR2 Human VEGFR2 Human Inquiry
BABFV-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 PDGFR2 Mouse VEGFR2 Mouse Inquiry
FABVC-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc PDGFR2 Human VEGFR2 Human Inquiry
FABVC-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc PDGFR2 Mouse VEGFR2 Mouse Inquiry
SCDBC-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 PDGFR2 Human VEGFR2 Human Inquiry
SCDBC-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSDBC-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 PDGFR2 Human VEGFR2 Human Inquiry
BSDBC-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 PDGFR2 Mouse VEGFR2 Mouse Inquiry
SCDBF-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc PDGFR2 Human VEGFR2 Human Inquiry
SCDBF-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFVF-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc PDGFR2 Human VEGFR2 Human Inquiry
BSFVF-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSDBF-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc PDGFR2 Human VEGFR2 Human Inquiry
BSDBF-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSTF-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSTF-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSCFV-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scFv-Fc) Human scFv-Fc PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSCFV-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scFv-Fc) Human scFv-Fc PDGFR2 Mouse VEGFR2 Mouse Inquiry
MNAB-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Miniantibody) Human Miniantibody PDGFR2 Mouse VEGFR2 Mouse Inquiry
MNAB-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Miniantibody) Human Miniantibody PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFC-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scFv-CH3) Human scFv-CH3 PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFC-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scFv-CH3) Human scFv-CH3 PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSCC-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSCC-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL PDGFR2 Mouse VEGFR2 Mouse Inquiry
BIBD-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Bibody) Human Bibody PDGFR2 Mouse VEGFR2 Mouse Inquiry
BIBD-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Bibody) Human Bibody PDGFR2 Mouse VEGFR2 Mouse Inquiry
FABFV-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Fab-Fv) Human Fab-Fv PDGFR2 Mouse VEGFR2 Mouse Inquiry
MiniB-H350 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Bispecific Antibody (Minibody) Human Minibody PDGFR2 Human VEGFR2 Human Inquiry
MiniB-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Minibody) Human Minibody PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-SAR035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-SAR017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-NGB035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-NGB017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-MEL035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-MEL017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-BGN035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-BGN017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-ABR035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-ABR017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-PAP035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-PAP017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-SAP035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-SAP017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-RTA035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-RTA017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-GEL035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-GEL017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-PE035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-PE017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-DT035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-DT017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFV-SAR035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFV-SAR017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFV-NGB035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFV-NGB017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFV-MEL035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFV-MEL017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFV-BGN035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFV-BGN017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFV-ABR035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFV-ABR017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFV-PAP035 Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Human VEGFR2 Human Inquiry
BSFV-PAP017 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin PDGFR2 Mouse VEGFR2 Mouse Inquiry
SCDB-H348 Recombinant Human Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody PDGFR2 Human VEGFR2 Human Inquiry
FABIG-H348 Recombinant Human Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Fab-IgG) Human Fab-IgG PDGFR2 Human VEGFR2 Human Inquiry
TRIB-H350 Recombinant Human Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv PDGFR2 Human VEGFR2 Human Inquiry
BSIG-H348 Human Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (IgG-IgG) Human IgG-IgG PDGFR2 Human VEGFR2 Human Inquiry
CROSSAB-H348 Recombinant Human Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (CrossMab) Human CrossMab PDGFR2 Human VEGFR2 Human Inquiry
IGFV-H348 Recombinant Human Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (IgG-scFv) Human IgG-scFv PDGFR2 Human VEGFR2 Human Inquiry
BSDB-H348 Recombinant Human Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Diabody) Human Diabody PDGFR2 Human VEGFR2 Human Inquiry
BSFAB-H348 Recombinant Human Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Tandem Fab) Human Tandem Fab PDGFR2 Human VEGFR2 Human Inquiry
BSFV-H347 Recombinant Human Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Tandem scFv) Human Tandem scFv PDGFR2 Human VEGFR2 Human Inquiry
SCDB-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody PDGFR2 Mouse VEGFR2 Mouse Inquiry
FABIG-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Fab-IgG) Human Fab-IgG PDGFR2 Mouse VEGFR2 Mouse Inquiry
TRIB-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSIG-187 Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (IgG-IgG) Human IgG-IgG PDGFR2 Mouse VEGFR2 Mouse Inquiry
CROSSAB-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (CrossMab) Human CrossMab PDGFR2 Mouse VEGFR2 Mouse Inquiry
IGFV-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (IgG-scFv) Human IgG-scFv PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSDB-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Diabody) Human Diabody PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFAB-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Tandem Fab) Human Tandem Fab PDGFR2 Mouse VEGFR2 Mouse Inquiry
BSFV-187 Recombinant Anti-PDGFR2 x Anti-VEGFR2 Bispecific Antibody (Tandem scFv) Human Tandem scFv PDGFR2 Mouse VEGFR2 Mouse Inquiry

Background

Fig 1. The structure of PDGFRA. (Li, et al., 2017)Fig.1 The structure of PDGFRA.1

Platelet-derived growth factor receptor 2 (PDGFR2), also known as PDGFRA, is a transmembrane receptor tyrosine kinase. It exists in a variety of cell types, including fibroblasts and smooth muscle cells, and it is essential for cell proliferation, migration, and survival. PDGFRA activates downstream signaling pathways such as the PI3K-Akt and Ras-MAPK pathways by binding to its ligands, which are members of the platelet-derived growth factor (PDGF) family. PDGFR2 has been discovered to be overexpressed in a variety of cancers, including glioblastoma, gastrointestinal stromal tumors, and lung cancer, making it an attractive target for cancer therapy. In addition to cancer therapy, PDGFR2 inhibitors have also been investigated for their potential application in the treatment of other diseases, such as idiopathic pulmonary fibrosis and atherosclerosis.

Reference

  1. Li, Ke, et al. “Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions.” Oncotarget vol. 8,36 60589-60604. 8 Mar. 2017.
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