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Background
Product List
Background
PTK7 (Protein Tyrosine Kinase 7), also known as colon carcinoma kinase 4 (CCK4), is an evolutionarily conserved transmembrane receptor belonging to the pseudokinase family of receptor tyrosine kinases (RTKs). Structurally, it comprises an extracellular domain with seven immunoglobulin-like loops and two fibronectin type III repeats, a transmembrane helix, and an intracellular pseudokinase domain lacking catalytic activity due to critical residue substitutions in its ATP-binding pocket. This unique architecture enables PTK7 to function as a co-receptor in Wnt/β-catenin signaling pathways through interactions with Wnt ligands and Frizzled receptors, mediating planar cell polarity during embryonic development and tissue morphogenesis. Biochemically, PTK7 orchestrates cell migration and invasion through cytoskeletal reorganization via RAC1 and JNK activation. Emerging evidence highlights its dual role in oncology: while acting as a tumor suppressor in acute myeloid leukemia by modulating cell differentiation, it paradoxically promotes metastasis in solid tumors like colorectal and triple-negative breast cancers through matrix metalloproteinase activation and epithelial-mesenchymal transition.
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