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SCLC1 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H277 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human SCLC1 Human Inquiry
T-BSDB-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse SCLC1 Mouse Inquiry
SCIGG-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human SCLC1 Human Inquiry
SCIGG-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse SCLC1 Mouse Inquiry
FVTIG-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human SCLC1 Human Inquiry
FVTIG-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse SCLC1 Mouse Inquiry
BSSG-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human SCLC1 Human Inquiry
BSSG-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse SCLC1 Mouse Inquiry
IGLFV-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human SCLC1 Human Inquiry
IGLFV-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse SCLC1 Mouse Inquiry
BSGV-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse SCLC1 Mouse Inquiry
BSGV-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse SCLC1 Mouse Inquiry
BSDG-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human SCLC1 Human Inquiry
BSDG-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse SCLC1 Mouse Inquiry
BABFV-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human SCLC1 Human Inquiry
BABFV-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse SCLC1 Mouse Inquiry
FABVC-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human SCLC1 Human Inquiry
FABVC-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse SCLC1 Mouse Inquiry
SCDBC-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human SCLC1 Human Inquiry
SCDBC-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse SCLC1 Mouse Inquiry
BSDBC-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human SCLC1 Human Inquiry
BSDBC-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse SCLC1 Mouse Inquiry
SCDBF-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human SCLC1 Human Inquiry
SCDBF-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse SCLC1 Mouse Inquiry
BSFVF-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human SCLC1 Human Inquiry
BSFVF-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse SCLC1 Mouse Inquiry
BSDBF-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human SCLC1 Human Inquiry
BSDBF-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse SCLC1 Mouse Inquiry
BSTF-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse SCLC1 Mouse Inquiry
BSTF-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse SCLC1 Mouse Inquiry
BSCFV-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse SCLC1 Mouse Inquiry
BSCFV-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse SCLC1 Mouse Inquiry
MNAB-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse SCLC1 Mouse Inquiry
MNAB-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse SCLC1 Mouse Inquiry
BSFC-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse SCLC1 Mouse Inquiry
BSFC-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse SCLC1 Mouse Inquiry
BSCC-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse SCLC1 Mouse Inquiry
BSCC-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse SCLC1 Mouse Inquiry
BIBD-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse SCLC1 Mouse Inquiry
BIBD-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse SCLC1 Mouse Inquiry
FABFV-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human SCLC1 Human Inquiry
FABFV-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse SCLC1 Mouse Inquiry
MiniB-H279 Recombinant Human Anti-CD3 x Human Anti-SCLC1 Bispecific Antibody (Minibody) Human Minibody CD3 Human SCLC1 Human Inquiry
MiniB-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse SCLC1 Mouse Inquiry
SCTB-H172 Recombinant Human Anti-SCLC1 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human SCLC1 Human Inquiry
SCDB-H277 Recombinant Human Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human SCLC1 Human Inquiry
FABIG-H277 Recombinant Human Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human SCLC1 Human Inquiry
TRIB-H279 Recombinant Human Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human SCLC1 Human Inquiry
BSIG-H277 Human Anti-CD3 x Anti-SCLC1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human SCLC1 Human Inquiry
CROSSAB-H277 Recombinant Human Anti-CD3 x Anti-SCLC1 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human SCLC1 Human Inquiry
IGFV-H277 Recombinant Human Anti-CD3 x Anti-SCLC1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human SCLC1 Human Inquiry
BSDB-H277 Recombinant Human Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Diabody) Human Diabody CD3 Human SCLC1 Human Inquiry
BSFAB-H277 Recombinant Human Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human SCLC1 Human Inquiry
BSFV-H277 Recombinant Human Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human SCLC1 Human Inquiry
SCTB-076 Recombinant Anti-SCLC1 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse SCLC1 Mouse Inquiry
SCDB-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse SCLC1 Mouse Inquiry
FABIG-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse SCLC1 Mouse Inquiry
TRIB-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse SCLC1 Mouse Inquiry
BSIG-103 Anti-CD3 x Anti-SCLC1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse SCLC1 Mouse Inquiry
CROSSAB-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse SCLC1 Mouse Inquiry
IGFV-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse SCLC1 Mouse Inquiry
BSDB-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse SCLC1 Mouse Inquiry
BSFAB-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse SCLC1 Mouse Inquiry
BSFV-103 Recombinant Anti-CD3 x Anti-SCLC1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse SCLC1 Mouse Inquiry

Background

Diseases associated with SCLC1, small cell lung cancer (SCLC) stands out as an exceptionally aggressive form of cancer, characterized by a poor prognosis and a high metastatic rate. Representing a significant proportion of lung cancer cases, SCLC exhibits a notable prevalence of somatic mutations induced by tobacco carcinogens, underscoring its strong association with smoking. Platinum-based chemotherapy serves as a primary therapeutic approach for SCLC patients. SCLC has a high mutational burden, including copy-number gains in genes encoding MYC family members, enzymes associated with receptor tyrosine kinases, Notch family proteins, chromatin remodeling, and tumor-suppressor genes RB1 and TP53 inactivation. Furthermore, the activation of the PI3K/Akt/mTOR pathway emerges as a promising therapeutic target, given its frequent involvement in SCLC.

An intricate interplay between harmony of signaling and metabolic pathways in SCLC. (Krencz, et al., 2021) Fig.1 An intricate interplay between harmony of signaling and metabolic pathways in SCLC.1

Reference

  1. Krencz, Ildiko, et al. "Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations." Cancer and Metastasis Reviews 40.4 (2021): 1141-1157.
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