Home > Products > By Targets > SHH
SHH Bispecific Antibodies
Product List Background

Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H317 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DNMT1 Human SHH Human Inquiry
T-BSDB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DNMT1 Mouse SHH Mouse Inquiry
SCIGG-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scIgG) Human Single chain IgGs DNMT1 Human SHH Human Inquiry
SCIGG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scIgG) Human Single chain IgGs DNMT1 Mouse SHH Mouse Inquiry
FVTIG-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DNMT1 Human SHH Human Inquiry
FVTIG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DNMT1 Mouse SHH Mouse Inquiry
BSSG-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-IgG) Human scFv-IgG DNMT1 Human SHH Human Inquiry
BSSG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-IgG) Human scFv-IgG DNMT1 Mouse SHH Mouse Inquiry
IGLFV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DNMT1 Human SHH Human Inquiry
IGLFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DNMT1 Mouse SHH Mouse Inquiry
BSGV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (IgG-Fv) Human IgG-Fv DNMT1 Mouse SHH Mouse Inquiry
BSGV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-Fv) Human IgG-Fv DNMT1 Mouse SHH Mouse Inquiry
BSDG-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Fv-IgG) Human Fv-IgG DNMT1 Human SHH Human Inquiry
BSDG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fv-IgG) Human Fv-IgG DNMT1 Mouse SHH Mouse Inquiry
BABFV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DNMT1 Human SHH Human Inquiry
BABFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DNMT1 Mouse SHH Mouse Inquiry
FABVC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DNMT1 Human SHH Human Inquiry
FABVC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DNMT1 Mouse SHH Mouse Inquiry
SCDBC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DNMT1 Human SHH Human Inquiry
SCDBC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DNMT1 Mouse SHH Mouse Inquiry
BSDBC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DNMT1 Human SHH Human Inquiry
BSDBC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DNMT1 Mouse SHH Mouse Inquiry
SCDBF-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DNMT1 Human SHH Human Inquiry
SCDBF-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DNMT1 Mouse SHH Mouse Inquiry
BSFVF-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DNMT1 Human SHH Human Inquiry
BSFVF-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DNMT1 Mouse SHH Mouse Inquiry
BSDBF-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DNMT1 Human SHH Human Inquiry
BSDBF-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DNMT1 Mouse SHH Mouse Inquiry
BSTF-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DNMT1 Mouse SHH Mouse Inquiry
BSTF-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DNMT1 Mouse SHH Mouse Inquiry
BSCFV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-Fc) Human scFv-Fc DNMT1 Mouse SHH Mouse Inquiry
BSCFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-Fc) Human scFv-Fc DNMT1 Mouse SHH Mouse Inquiry
MNAB-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Miniantibody) Human Miniantibody DNMT1 Mouse SHH Mouse Inquiry
MNAB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Miniantibody) Human Miniantibody DNMT1 Mouse SHH Mouse Inquiry
BSFC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-CH3) Human scFv-CH3 DNMT1 Mouse SHH Mouse Inquiry
BSFC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-CH3) Human scFv-CH3 DNMT1 Mouse SHH Mouse Inquiry
BSCC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DNMT1 Mouse SHH Mouse Inquiry
BSCC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DNMT1 Mouse SHH Mouse Inquiry
BIBD-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Bibody) Human Bibody DNMT1 Mouse SHH Mouse Inquiry
BIBD-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Bibody) Human Bibody DNMT1 Mouse SHH Mouse Inquiry
FABFV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Fab-Fv) Human Fab-Fv DNMT1 Human SHH Human Inquiry
FABFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-Fv) Human Fab-Fv DNMT1 Mouse SHH Mouse Inquiry
MiniB-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Minibody) Human Minibody DNMT1 Human SHH Human Inquiry
MiniB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Minibody) Human Minibody DNMT1 Mouse SHH Mouse Inquiry
SCDB-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DNMT1 Human SHH Human Inquiry
FABIG-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-IgG) Human Fab-IgG DNMT1 Human SHH Human Inquiry
TRIB-H319 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DNMT1 Human SHH Human Inquiry
BSIG-H317 Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-IgG) Human IgG-IgG DNMT1 Human SHH Human Inquiry
CROSSAB-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (CrossMab) Human CrossMab DNMT1 Human SHH Human Inquiry
IGFV-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-scFv) Human IgG-scFv DNMT1 Human SHH Human Inquiry
BSDB-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Diabody) Human Diabody DNMT1 Human SHH Human Inquiry
BSFAB-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem Fab) Human Tandem Fab DNMT1 Human SHH Human Inquiry
BSFV-H316 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv) Human Tandem scFv DNMT1 Human SHH Human Inquiry
SCDB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DNMT1 Mouse SHH Mouse Inquiry
FABIG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-IgG) Human Fab-IgG DNMT1 Mouse SHH Mouse Inquiry
TRIB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DNMT1 Mouse SHH Mouse Inquiry
BSIG-150 Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-IgG) Human IgG-IgG DNMT1 Mouse SHH Mouse Inquiry
CROSSAB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (CrossMab) Human CrossMab DNMT1 Mouse SHH Mouse Inquiry
IGFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-scFv) Human IgG-scFv DNMT1 Mouse SHH Mouse Inquiry
BSDB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Diabody) Human Diabody DNMT1 Mouse SHH Mouse Inquiry
BSFAB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem Fab) Human Tandem Fab DNMT1 Mouse SHH Mouse Inquiry
BSFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv) Human Tandem scFv DNMT1 Mouse SHH Mouse Inquiry

Background

The classical pathway to activate SHH cascades. (Wang, Wanchen, et al., 2022) Fig.1 The classical pathway to activate SHH cascades. 1

Sonic Hedgehog (SHH) is the primary ligand for the Hedgehog (HH) signaling pathway that regulates embryonic development and tissue homeostasis. SHH can be released to the cell surface via exosomes. Both classical and non-classical pathways can activate the SHH cascade. Due to the SHH ligand-dependent interaction, the binding of PTCH1 and SHH eliminates the inhibitory effect of PTCH1 on smoothened (Smo), thereby enabling the activation of SMO. Activated Smo results in the dissociation of the Gli-Sufu complex and promotes nuclear translocation of Gli. This leads to enhanced expression of genes that control cell proliferation (e.g., Cyclin D1, Myc), cycling (e.g., CCND2, CCNE1), and other processes. Non-classical cascades can trigger a number of cancer-related cellular responses, such as apoptosis, migration, and cytoskeletal alignment. Alterations in skeletal development can be triggered by any impact on SHH expression or function during early embryonic development. Moreover, for cancers like Ewing's sarcoma, activation of the SHH cascade leads to increased cell proliferation and tumor growth.

Reference

  1. Wang, Wanchen, Ryo Shiraishi, and Daisuke Kawauchi. "Sonic hedgehog signaling in cerebellar development and cancer." Frontiers in Cell and Developmental Biology 10 (2022): 864035.
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Welcome! For price inquiries, we will get back to you as soon as possible.

To order, please email

INQUIRY
Related Sections

SERVICES

PRODUCTS

PLATFORMS

quality
ISO 9001 Certified - Creative Biolabs Quality Management System.
© 2026 Creative Biolabs. All Rights Reserved.