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TNF & VEGFA Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0824-N2 Recombinant Anti-TNF sdAb x Anti-VEGFA sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb TNF llama VEGFA llama Inquiry
KN-0824-N1 Recombinant Human Anti-TNF x Human Anti-VEGFA Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc TNF Human VEGFA Human Inquiry
BSCC-H195 Recombinant Human Anti-albumin x Human Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL albumin Mouse TNF Mouse Inquiry
BSCC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL NGF Mouse TNF Mouse Inquiry
BSCC-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17 Mouse TNF Mouse Inquiry
BSCC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ang2 Mouse VEGFA Mouse Inquiry
BSCC-007 Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL albumin Mouse TNF Mouse Inquiry
BIBD-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF Mouse TNF Mouse Inquiry
BIBD-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 Mouse TNF Mouse Inquiry
BIBD-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Bibody) Human Bibody Ang2 Mouse VEGFA Mouse Inquiry
BIBD-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody Albumin Mouse TNF Mouse Inquiry
BIBD-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF Mouse TNF Mouse Inquiry
BIBD-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 Mouse TNF Mouse Inquiry
BIBD-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Bibody) Human Bibody Ang2 Mouse VEGFA Mouse Inquiry
BIBD-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Bibody) Human Bibody Albumin Mouse TNF Mouse Inquiry
FABFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF Human TNF Human Inquiry
FABFV-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Human TNF Human Inquiry
FABFV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ang2 Human VEGFA Human Inquiry
FABFV-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin Human TNF Human Inquiry
FABFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF Mouse TNF Mouse Inquiry
FABFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Mouse TNF Mouse Inquiry
FABFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ang2 Mouse VEGFA Mouse Inquiry
FABFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin Mouse TNF Mouse Inquiry
MiniB-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF Human TNF Human Inquiry
MiniB-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 Human TNF Human Inquiry
MiniB-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Minibody) Human Minibody Ang2 Human VEGFA Human Inquiry
MiniB-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody Albumin Human TNF Human Inquiry
MiniB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF Mouse TNF Mouse Inquiry
MiniB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 Mouse TNF Mouse Inquiry
MiniB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Minibody) Human Minibody Ang2 Mouse VEGFA Mouse Inquiry
MiniB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Minibody) Human Minibody Albumin Mouse TNF Mouse Inquiry
SCDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF Human TNF Human Inquiry
SCDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Human TNF Human Inquiry
SCDB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ang2 Human VEGFA Human Inquiry
SCDB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin Human TNF Human Inquiry
FABIG-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF Human TNF Human Inquiry
FABIG-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Human TNF Human Inquiry
FABIG-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ang2 Human VEGFA Human Inquiry
FABIG-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin Human TNF Human Inquiry
TRIB-H346 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv NGF Human TNF Human Inquiry
TRIB-H341 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Human TNF Human Inquiry
TRIB-H196 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Ang2 Human VEGFA Human Inquiry
TRIB-H195 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Albumin Human TNF Human Inquiry
BSIG-H344 Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF Human TNF Human Inquiry
BSIG-H339 Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Human TNF Human Inquiry
BSIG-H194 Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ang2 Human VEGFA Human Inquiry
BSIG-H193 Human Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin Human TNF Human Inquiry
CROSSAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab NGF Human TNF Human Inquiry
CROSSAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 Human TNF Human Inquiry
CROSSAB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (CrossMab) Human CrossMab Ang2 Human VEGFA Human Inquiry
CROSSAB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab Albumin Human TNF Human Inquiry
IGFV-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF Human TNF Human Inquiry
IGFV-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Human TNF Human Inquiry
IGFV-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ang2 Human VEGFA Human Inquiry
IGFV-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin Human TNF Human Inquiry
BSDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF Human TNF Human Inquiry
BSDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 Human TNF Human Inquiry
BSDB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody) Human Diabody Ang2 Human VEGFA Human Inquiry
BSDB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody) Human Diabody Albumin Human TNF Human Inquiry
BSFAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF Human TNF Human Inquiry
BSFAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Human TNF Human Inquiry
BSFAB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ang2 Human VEGFA Human Inquiry
BSFAB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin Human TNF Human Inquiry
BSFV-H343 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF Human TNF Human Inquiry
BSFV-H337 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Human TNF Human Inquiry
BSFV-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ang2 Human VEGFA Human Inquiry
BSFV-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin Human TNF Human Inquiry
SCDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF Mouse TNF Mouse Inquiry
SCDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Mouse TNF Mouse Inquiry
SCDB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ang2 Mouse VEGFA Mouse Inquiry
SCDB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin Mouse TNF Mouse Inquiry
FABIG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF Mouse TNF Mouse Inquiry
FABIG-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Mouse TNF Mouse Inquiry
FABIG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ang2 Mouse VEGFA Mouse Inquiry
FABIG-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin Mouse TNF Mouse Inquiry
TRIB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv NGF Mouse TNF Mouse Inquiry
TRIB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Mouse TNF Mouse Inquiry
TRIB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Ang2 Mouse VEGFA Mouse Inquiry
TRIB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Albumin Mouse TNF Mouse Inquiry
BSIG-182 Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF Mouse TNF Mouse Inquiry
BSIG-175 Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Mouse TNF Mouse Inquiry
BSIG-008 Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ang2 Mouse VEGFA Mouse Inquiry
BSIG-007 Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin Mouse TNF Mouse Inquiry
CROSSAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 Mouse TNF Mouse Inquiry
CROSSAB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (CrossMab) Human CrossMab Ang2 Mouse VEGFA Mouse Inquiry
CROSSAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab Albumin Mouse TNF Mouse Inquiry
IGFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF Mouse TNF Mouse Inquiry
IGFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Mouse TNF Mouse Inquiry
IGFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ang2 Mouse VEGFA Mouse Inquiry
IGFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin Mouse TNF Mouse Inquiry
BSDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF Mouse TNF Mouse Inquiry
BSDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 Mouse TNF Mouse Inquiry
BSDB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody) Human Diabody Ang2 Mouse VEGFA Mouse Inquiry
BSDB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody) Human Diabody Albumin Mouse TNF Mouse Inquiry
BSFAB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF Mouse TNF Mouse Inquiry
BSFAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Mouse TNF Mouse Inquiry
BSFAB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ang2 Mouse VEGFA Mouse Inquiry
BSFAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin Mouse TNF Mouse Inquiry
BSFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF Mouse TNF Mouse Inquiry
BSFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Mouse TNF Mouse Inquiry
BSFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ang2 Mouse VEGFA Mouse Inquiry
BSFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin Mouse TNF Mouse Inquiry

Background

Tumor necrosis factor (TNF) is a pro-inflammatory cytokine driving pathological processes in autoimmune diseases (e.g., rheumatoid arthritis) and chronic inflammatory disorders by activating NF-κB and MAPK pathways. Vascular endothelial growth factor A (VEGFA) regulates angiogenesis and vascular permeability, contributing to tumor progression and retinal pathologies like diabetic macular edema. Bispecific antibodies targeting TNF and VEGFA synergistically inhibit inflammatory cascades and pathological angiogenesis through a tetravalent symmetric structure, enhancing binding avidity. This dual blockade mechanism enables simultaneous modulation of immune dysregulation and vascular remodeling, offering therapeutic advantages in oncology (e.g., solid tumors with inflammatory microenvironments) and complex inflammatory-angiogenic diseases (e.g., age-related macular degeneration). Engineered Fc domains with reduced effector functions (e.g., minimized ADCC/ADCP) further improve safety profiles, as demonstrated in clinical studies with similar bispecific formats. These agents are poised to address unmet needs in diseases where TNF and VEGFA pathways interdependently fuel pathogenesis.

TNF and VEGFA pathways in the tumor. (OA Literature)Fig.1 Role of TNF and VEGFA in tumor.1,2

References

  1. Sheng, Yuqiao et al. "TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors." Frontiers in Immunology vol. 9 1170. 28 May. 2018, doi:10.3389/fimmu.2018.01170. Distributed under Open Access license CC BY 4.0, without modification.
  2. Sa-Nguanraksa, Doonyapat, and Pornchai O-Charoenrat. "The role of vascular endothelial growth factor a polymorphisms in breast cancer." International Journal of Molecular Sciences vol. 13,11 14845-64. 13 Nov. 2012, doi:10.3390/ijms131114845. Distributed under Open Access license CC BY 3.0, without modification.
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