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TNFα Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H309 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CEA Human TNFα Human Inquiry
T-BSDB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CEA Mouse TNFα Mouse Inquiry
SCIGG-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (scIgG) Human Single chain IgGs CEA Human TNFα Human Inquiry
FABVC-396 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc CEA Mouse TNFα llama Inquiry
BSSG-396 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (sdAb-IgG) Human sdAb-IgG CEA Mouse TNFα llama Inquiry
HCAB-041 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb CEA llama TNFα llama Inquiry
BIBD-396 Recombinant Anti-CEA x Anti-TNFα VHH BispecificAntibody (Bibody) Human Bibody CEA Mouse TNFα llama Inquiry
TRIB-395 Recombinant Anti-CEA x Anti-TNFα VHH Bispecific Antibody (Fab-sdAb-sdAb) Human Fab-sdAb-sdAb CEA Mouse TNFα llama Inquiry
IGVHH-041 Recombinant Anti-CEA x Anti-TNFα sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb CEA Mouse TNFα llama Inquiry
BIVHH-041 Recombinant Anti-CEA sdAb x Anti-TNFα sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb CEA llama TNFα llama Inquiry
SCIGG-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scIgG) Human Single chain IgGs CEA Mouse TNFα Mouse Inquiry
FVTIG-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CEA Human TNFα Human Inquiry
FVTIG-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CEA Mouse TNFα Mouse Inquiry
BSSG-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (scFv-IgG) Human scFv-IgG CEA Human TNFα Human Inquiry
BSSG-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-IgG) Human scFv-IgG CEA Mouse TNFα Mouse Inquiry
IGLFV-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CEA Human TNFα Human Inquiry
IGLFV-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CEA Mouse TNFα Mouse Inquiry
BSGV-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (IgG-Fv) Human IgG-Fv CEA Human TNFα Human Inquiry
BSGV-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (IgG-Fv) Human IgG-Fv CEA Mouse TNFα Mouse Inquiry
BSDG-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Fv-IgG) Human Fv-IgG CEA Human TNFα Human Inquiry
BSDG-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Fv-IgG) Human Fv-IgG CEA Mouse TNFα Mouse Inquiry
BABFV-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CEA Human TNFα Human Inquiry
BABFV-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CEA Mouse TNFα Mouse Inquiry
FABVC-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CEA Human TNFα Human Inquiry
FABVC-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CEA Mouse TNFα Mouse Inquiry
SCDBC-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CEA Human TNFα Human Inquiry
SCDBC-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CEA Mouse TNFα Mouse Inquiry
BSDBC-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CEA Human TNFα Human Inquiry
BSDBC-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CEA Mouse TNFα Mouse Inquiry
SCDBF-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CEA Human TNFα Human Inquiry
SCDBF-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CEA Mouse TNFα Mouse Inquiry
BSFVF-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CEA Human TNFα Human Inquiry
BSFVF-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CEA Mouse TNFα Mouse Inquiry
BSDBF-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CEA Human TNFα Human Inquiry
BSDBF-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CEA Mouse TNFα Mouse Inquiry
BSTF-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CEA Human TNFα Human Inquiry
BSTF-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CEA Mouse TNFα Mouse Inquiry
BSCFV-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (scFv-Fc) Human scFv-Fc CEA Human TNFα Human Inquiry
BSCFV-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-Fc) Human scFv-Fc CEA Mouse TNFα Mouse Inquiry
MNAB-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Miniantibody) Human Miniantibody CEA Human TNFα Human Inquiry
MNAB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Miniantibody) Human Miniantibody CEA Mouse TNFα Mouse Inquiry
BSFC-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (scFv-CH3) Human scFv-CH3 CEA Human TNFα Human Inquiry
BSFC-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-CH3) Human scFv-CH3 CEA Mouse TNFα Mouse Inquiry
BSCC-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CEA Human TNFα Human Inquiry
BSCC-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CEA Mouse TNFα Mouse Inquiry
BIBD-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Bibody) Human Bibody CEA Human TNFα Human Inquiry
BIBD-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Bibody) Human Bibody CEA Mouse TNFα Mouse Inquiry
FABFV-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Fab-Fv) Human Fab-Fv CEA Human TNFα Human Inquiry
FABFV-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-Fv) Human Fab-Fv CEA Mouse TNFα Mouse Inquiry
MiniB-H311 Recombinant Human Anti-CEA x Human Anti-TNFα Bispecific Antibody (Minibody) Human Minibody CEA Human TNFα Human Inquiry
MiniB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Minibody) Human Minibody CEA Mouse TNFα Mouse Inquiry
SCDB-H309 Recombinant Human Anti-CEA x Anti-TNFα Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CEA Human TNFα Human Inquiry
FABIG-H309 Recombinant Human Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA Human TNFα Human Inquiry
TRIB-H311 Recombinant Human Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CEA Human TNFα Human Inquiry
BSIG-H309 Human Anti-CEA x Anti-TNFα Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA Human TNFα Human Inquiry
CROSSAB-H309 Recombinant Human Anti-CEA x Anti-TNFα Bispecific Antibody (CrossMab) Human CrossMab CEA Human TNFα Human Inquiry
IGFV-H309 Recombinant Human Anti-CEA x Anti-TNFα Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA Human TNFα Human Inquiry
BSDB-H309 Recombinant Human Anti-CEA x Anti-TNFα Bispecific Antibody (Diabody) Human Diabody CEA Human TNFα Human Inquiry
BSFAB-H309 Recombinant Human Anti-CEA x Anti-TNFα Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA Human TNFα Human Inquiry
BSFV-H309 Recombinant Human Anti-CEA x Anti-TNFα Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA Human TNFα Human Inquiry
SCDB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CEA Mouse TNFα Mouse Inquiry
FABIG-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA Mouse TNFα Mouse Inquiry
TRIB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CEA Mouse TNFα Mouse Inquiry
BSIG-142 Anti-CEA x Anti-TNFα Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA Mouse TNFα Mouse Inquiry
CROSSAB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (CrossMab) Human CrossMab CEA Mouse TNFα Mouse Inquiry
IGFV-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA Mouse TNFα Mouse Inquiry
BSDB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Diabody) Human Diabody CEA Mouse TNFα Mouse Inquiry
BSFAB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA Mouse TNFα Mouse Inquiry
BSFV-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA Mouse TNFα Mouse Inquiry

Background

Fig.1 TNF induced cell death signaling. (Webster and Domagoj, 2020)Fig.1 TNF induced cell death signaling.1

Tumor Necrosis Factor-alpha (TNFα) is a central cytokine, or cell-signaling protein, which modulates immune response and inflammation. It is mainly generated by immune system cells ranging from T-cells, monocytes, and macrophages. It acts as a potent mediator of inflammation, stimulating the release of other inflammatory molecules and promoting the recruitment of immune cells to the region of injury or infection. TNFα also plays a role in apoptosis, cell proliferation, and differentiation. TNFα works by binding to its receptors, TNFR1 and TNFR2, on the surface of target cells. This interaction triggers signaling pathways that activate immune responses and regulate cell survival or death. TNFα has been extensively studied in the context of autoimmune diseases, such as rheumatoid arthritis and Crohn's disease, where excessive TNFα production leads to chronic inflammation. Therapeutic interventions targeting TNFα, like monoclonal antibodies, have been developed and successfully employed to suppress its activity and alleviate symptoms in these conditions.

Reference

  1. Webster, Joshua D., and Domagoj Vucic. "The balance of TNF mediated pathways regulates inflammatory cell death signaling in healthy and diseased tissues." Frontiers in Cell and Developmental Biology 8 (2020): 365.
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