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TNF Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSTF-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17 Human TNF Human Inquiry
BSTF-H195 Recombinant Human Anti-albumin x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv albumin Human TNF Human Inquiry
BSTF-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv NGF Mouse TNF Mouse Inquiry
BSTF-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17 Mouse TNF Mouse Inquiry
BSTF-007 Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv albumin Mouse TNF Mouse Inquiry
BSCFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-Fc NGF Human TNF Human Inquiry
BSCFV-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17 Human TNF Human Inquiry
BSCFV-H195 Recombinant Human Anti-albumin x Human Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-Fc albumin Human TNF Human Inquiry
BSCFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-Fc NGF Mouse TNF Mouse Inquiry
BSCFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17 Mouse TNF Mouse Inquiry
BSCFV-007 Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-Fc albumin Mouse TNF Mouse Inquiry
MNAB-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Miniantibody) Human Miniantibody NGF Human TNF Human Inquiry
MNAB-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Miniantibody) Human Miniantibody IL17 Human TNF Human Inquiry
MNAB-H195 Recombinant Human Anti-albumin x Human Anti-TNF Bispecific Antibody (Miniantibody) Human Miniantibody albumin Human TNF Human Inquiry
MNAB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Miniantibody) Human Miniantibody NGF Mouse TNF Mouse Inquiry
MNAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Miniantibody) Human Miniantibody IL17 Mouse TNF Mouse Inquiry
MNAB-007 Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (Miniantibody) Human Miniantibody albumin Mouse TNF Mouse Inquiry
BSFC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-CH3 NGF Human TNF Human Inquiry
BSFC-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17 Human TNF Human Inquiry
BSFC-H195 Recombinant Human Anti-albumin x Human Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-CH3 albumin Human TNF Human Inquiry
BSFC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-CH3 NGF Mouse TNF Mouse Inquiry
BSFC-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17 Mouse TNF Mouse Inquiry
BSFC-007 Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-CH3 albumin Mouse TNF Mouse Inquiry
BSCC-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL NGF Human TNF Human Inquiry
BSCC-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17 Human TNF Human Inquiry
BSCC-H195 Recombinant Human Anti-albumin x Human Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL albumin Human TNF Human Inquiry
BSCC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL NGF Mouse TNF Mouse Inquiry
BSCC-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17 Mouse TNF Mouse Inquiry
BSCC-007 Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL albumin Mouse TNF Mouse Inquiry
BIBD-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF Human TNF Human Inquiry
BIBD-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 Human TNF Human Inquiry
BIBD-H195 Recombinant Human Anti-albumin x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody albumin Human TNF Human Inquiry
BIBD-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF Mouse TNF Mouse Inquiry
BIBD-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 Mouse TNF Mouse Inquiry
BIBD-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Bibody) Human Bibody Albumin Mouse TNF Mouse Inquiry
FABFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF Human TNF Human Inquiry
FABFV-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Human TNF Human Inquiry
FABFV-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin Human TNF Human Inquiry
FABFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF Mouse TNF Mouse Inquiry
FABFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Mouse TNF Mouse Inquiry
FABFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin Mouse TNF Mouse Inquiry
MiniB-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF Human TNF Human Inquiry
MiniB-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 Human TNF Human Inquiry
MiniB-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody Albumin Human TNF Human Inquiry
MiniB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF Mouse TNF Mouse Inquiry
MiniB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 Mouse TNF Mouse Inquiry
MiniB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Minibody) Human Minibody Albumin Mouse TNF Mouse Inquiry
SCDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF Human TNF Human Inquiry
SCDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Human TNF Human Inquiry
SCDB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin Human TNF Human Inquiry
FABIG-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF Human TNF Human Inquiry
FABIG-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Human TNF Human Inquiry
FABIG-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin Human TNF Human Inquiry
TRIB-H346 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv NGF Human TNF Human Inquiry
TRIB-H341 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Human TNF Human Inquiry
TRIB-H195 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Albumin Human TNF Human Inquiry
BSIG-H344 Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF Human TNF Human Inquiry
BSIG-H339 Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Human TNF Human Inquiry
BSIG-H193 Human Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin Human TNF Human Inquiry
CROSSAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab NGF Human TNF Human Inquiry
CROSSAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 Human TNF Human Inquiry
CROSSAB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab Albumin Human TNF Human Inquiry
IGFV-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF Human TNF Human Inquiry
IGFV-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Human TNF Human Inquiry
IGFV-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin Human TNF Human Inquiry
BSDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF Human TNF Human Inquiry
BSDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 Human TNF Human Inquiry
BSDB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody) Human Diabody Albumin Human TNF Human Inquiry
BSFAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF Human TNF Human Inquiry
BSFAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Human TNF Human Inquiry
BSFAB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin Human TNF Human Inquiry
BSFV-H343 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF Human TNF Human Inquiry
BSFV-H337 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Human TNF Human Inquiry
BSFV-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin Human TNF Human Inquiry
SCDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF Mouse TNF Mouse Inquiry
SCDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Mouse TNF Mouse Inquiry
SCDB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin Mouse TNF Mouse Inquiry
FABIG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF Mouse TNF Mouse Inquiry
FABIG-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Mouse TNF Mouse Inquiry
FABIG-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin Mouse TNF Mouse Inquiry
TRIB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv NGF Mouse TNF Mouse Inquiry
TRIB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Mouse TNF Mouse Inquiry
TRIB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Albumin Mouse TNF Mouse Inquiry
BSIG-182 Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF Mouse TNF Mouse Inquiry
BSIG-175 Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Mouse TNF Mouse Inquiry
BSIG-007 Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin Mouse TNF Mouse Inquiry
CROSSAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 Mouse TNF Mouse Inquiry
CROSSAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab Albumin Mouse TNF Mouse Inquiry
IGFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF Mouse TNF Mouse Inquiry
IGFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Mouse TNF Mouse Inquiry
IGFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin Mouse TNF Mouse Inquiry
BSDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF Mouse TNF Mouse Inquiry
BSDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 Mouse TNF Mouse Inquiry
BSDB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody) Human Diabody Albumin Mouse TNF Mouse Inquiry
BSFAB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF Mouse TNF Mouse Inquiry
BSFAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Mouse TNF Mouse Inquiry
BSFAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin Mouse TNF Mouse Inquiry
BSFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF Mouse TNF Mouse Inquiry
BSFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Mouse TNF Mouse Inquiry
BSFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin Mouse TNF Mouse Inquiry

Background

TNF (Tumor necrosis factor), also named TNF-Alpha or cachectin, is a 157 aa pleiotropic cytokine and adipokine belonging to the TNF superfamily with a homologous TNF domain. Primarily generated by activated macrophages, natural killer cells, and T-lymphocytes, TNF has been recognized as a crucial factor regulating inflammatory responses by activating multiple inflammatory molecules, including other cytokines and chemokines, associated with many inflammatory and autoimmune diseases. TNF functions in various cells and facilitates biological activities in transmembrane and soluble form, by binding to its main receptors TNFR1 and TNFR2 and activating downstream signaling pathways, including NF-κB, MAPK pathways, and death signaling. Studies on TNF-signaling mechanisms during these years have expanded and inspired the treatment of many diseases, resulting in the development of related therapeutic tools and strategies.

General TNF-signaling pathway of TNFR1 and TNFR2 (Jang, et al, 2021) Fig.1 General TNF-signaling pathway of TNFR1 and TNFR2.1

Reference

  1. Jang, Dan-in, et al. "The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics." International journal of molecular sciences 22.5 (2021): 2719.
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