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TPBG Bispecific Antibodies
Product List Background

Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H280 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human TPBG Human Inquiry
T-BSDB-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse TPBG Mouse Inquiry
SCIGG-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human TPBG Human Inquiry
SCIGG-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse TPBG Mouse Inquiry
FVTIG-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human TPBG Human Inquiry
FVTIG-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse TPBG Mouse Inquiry
BSSG-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human TPBG Human Inquiry
BSSG-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse TPBG Mouse Inquiry
IGLFV-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human TPBG Human Inquiry
IGLFV-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse TPBG Mouse Inquiry
BSGV-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse TPBG Mouse Inquiry
BSGV-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse TPBG Mouse Inquiry
BSDG-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human TPBG Human Inquiry
BSDG-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse TPBG Mouse Inquiry
BABFV-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human TPBG Human Inquiry
BABFV-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse TPBG Mouse Inquiry
FABVC-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human TPBG Human Inquiry
FABVC-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse TPBG Mouse Inquiry
SCDBC-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human TPBG Human Inquiry
SCDBC-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse TPBG Mouse Inquiry
BSDBC-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human TPBG Human Inquiry
BSDBC-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse TPBG Mouse Inquiry
SCDBF-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human TPBG Human Inquiry
SCDBF-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse TPBG Mouse Inquiry
BSFVF-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human TPBG Human Inquiry
BSFVF-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse TPBG Mouse Inquiry
BSDBF-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human TPBG Human Inquiry
BSDBF-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse TPBG Mouse Inquiry
BSTF-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse TPBG Mouse Inquiry
BSTF-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse TPBG Mouse Inquiry
BSCFV-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse TPBG Mouse Inquiry
BSCFV-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse TPBG Mouse Inquiry
MNAB-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse TPBG Mouse Inquiry
MNAB-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse TPBG Mouse Inquiry
BSFC-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse TPBG Mouse Inquiry
BSFC-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse TPBG Mouse Inquiry
BSCC-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse TPBG Mouse Inquiry
BSCC-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse TPBG Mouse Inquiry
BIBD-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Bibody) Human Bibody CD3 Mouse TPBG Mouse Inquiry
BIBD-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Bibody) Human Bibody CD3 Mouse TPBG Mouse Inquiry
FABFV-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human TPBG Human Inquiry
FABFV-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse TPBG Mouse Inquiry
MiniB-H282 Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (Minibody) Human Minibody CD3 Human TPBG Human Inquiry
MiniB-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Minibody) Human Minibody CD3 Mouse TPBG Mouse Inquiry
SCTB-H175 Recombinant Human Anti-TPBG x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human TPBG Human Inquiry
SCDB-H280 Recombinant Human Anti-CD3 x Anti-TPBG Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human TPBG Human Inquiry
FABIG-H280 Recombinant Human Anti-CD3 x Anti-TPBG Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human TPBG Human Inquiry
TRIB-H282 Recombinant Human Anti-CD3 x Anti-TPBG Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human TPBG Human Inquiry
BSIG-H280 Human Anti-CD3 x Anti-TPBG Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human TPBG Human Inquiry
CROSSAB-H280 Recombinant Human Anti-CD3 x Anti-TPBG Bispecific Antibody (CrossMab) Human CrossMab CD3 Human TPBG Human Inquiry
IGFV-H280 Recombinant Human Anti-CD3 x Anti-TPBG Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human TPBG Human Inquiry
BSDB-H280 Recombinant Human Anti-CD3 x Anti-TPBG Bispecific Antibody (Diabody) Human Diabody CD3 Human TPBG Human Inquiry
BSFAB-H280 Recombinant Human Anti-CD3 x Anti-TPBG Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human TPBG Human Inquiry
BSFV-H280 Recombinant Human Anti-CD3 x Anti-TPBG Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human TPBG Human Inquiry
SCTB-079 Recombinant Anti-TPBG x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse TPBG Mouse Inquiry
SCDB-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse TPBG Mouse Inquiry
FABIG-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse TPBG Mouse Inquiry
TRIB-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse TPBG Mouse Inquiry
BSIG-106 Anti-CD3 x Anti-TPBG Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse TPBG Mouse Inquiry
CROSSAB-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse TPBG Mouse Inquiry
IGFV-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse TPBG Mouse Inquiry
BSDB-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Diabody) Human Diabody CD3 Mouse TPBG Mouse Inquiry
BSFAB-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse TPBG Mouse Inquiry
BSFV-106 Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse TPBG Mouse Inquiry

Background

Trophoblast glycoprotein (TPBG), also known as Wnt-activated inhibitory factor 1 (WAIF1), is a leucine-rich single-pass transmembrane glycoprotein believed to play a role in cell adhesion. Abundantly expressed in adult tissues, including bone, brain, and ovary, TPBG is also found in many tumor cells and correlates with unfavorable clinical outcomes in various cancers. Consequently, TPBG has been extensively studied in the context of cancer metastasis and embryonic stem cell differentiation. Functioning as an inhibitor of canonical Wnt signaling, TPBG concurrently activates non-canonical Wnt signaling. Recent research has unveiled TPBG's potential involvement in the development of Parkinson's Disease-like phenotypes in mice, suggesting a role in the neuronal function related to Parkinson's Disease.

Proposed mechanism of TPBG contributes to Parkinson's Disease pathogenesis. (Park, et al., 2021)Fig.1 Proposed mechanism of TPBG contributes to Parkinson's Disease pathogenesis.1

Reference

  1. Park, Sanghyun, et al. "Trophoblast glycoprotein is a new candidate gene for Parkinson’s disease." npj Parkinson's Disease 7.1 (2021): 110.
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