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VEGFR1 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H282 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human VEGFR1 Human Inquiry
T-BSDB-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse VEGFR1 Mouse Inquiry
SCIGG-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human VEGFR1 Human Inquiry
SCIGG-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse VEGFR1 Mouse Inquiry
FVTIG-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human VEGFR1 Human Inquiry
FVTIG-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse VEGFR1 Mouse Inquiry
BSSG-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human VEGFR1 Human Inquiry
BSSG-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse VEGFR1 Mouse Inquiry
IGLFV-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human VEGFR1 Human Inquiry
IGLFV-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse VEGFR1 Mouse Inquiry
BSGV-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Human VEGFR1 Human Inquiry
BSGV-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse VEGFR1 Mouse Inquiry
BSDG-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human VEGFR1 Human Inquiry
BSDG-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse VEGFR1 Mouse Inquiry
BABFV-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human VEGFR1 Human Inquiry
BABFV-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse VEGFR1 Mouse Inquiry
FABVC-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human VEGFR1 Human Inquiry
FABVC-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse VEGFR1 Mouse Inquiry
SCDBC-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human VEGFR1 Human Inquiry
SCDBC-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse VEGFR1 Mouse Inquiry
BSDBC-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human VEGFR1 Human Inquiry
BSDBC-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse VEGFR1 Mouse Inquiry
SCDBF-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human VEGFR1 Human Inquiry
SCDBF-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse VEGFR1 Mouse Inquiry
BSFVF-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human VEGFR1 Human Inquiry
BSFVF-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse VEGFR1 Mouse Inquiry
BSDBF-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human VEGFR1 Human Inquiry
BSDBF-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse VEGFR1 Mouse Inquiry
BSTF-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Human VEGFR1 Human Inquiry
BSTF-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse VEGFR1 Mouse Inquiry
BSCFV-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Human VEGFR1 Human Inquiry
BSCFV-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse VEGFR1 Mouse Inquiry
MNAB-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Human VEGFR1 Human Inquiry
MNAB-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse VEGFR1 Mouse Inquiry
BSFC-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Human VEGFR1 Human Inquiry
BSFC-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse VEGFR1 Mouse Inquiry
BSCC-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Human VEGFR1 Human Inquiry
BSCC-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse VEGFR1 Mouse Inquiry
BIBD-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Bibody) Human Bibody CD3 Human VEGFR1 Human Inquiry
BIBD-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse VEGFR1 Mouse Inquiry
FABFV-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human VEGFR1 Human Inquiry
FABFV-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse VEGFR1 Mouse Inquiry
MiniB-H284 Recombinant Human Anti-CD3 x Human Anti-VEGFR1 Bispecific Antibody (Minibody) Human Minibody CD3 Human VEGFR1 Human Inquiry
MiniB-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse VEGFR1 Mouse Inquiry
SCTB-H177 Recombinant Human Anti-VEGFR1 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human VEGFR1 Human Inquiry
SCDB-H282 Recombinant Human Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human VEGFR1 Human Inquiry
FABIG-H282 Recombinant Human Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human VEGFR1 Human Inquiry
TRIB-H284 Recombinant Human Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human VEGFR1 Human Inquiry
BSIG-H282 Human Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human VEGFR1 Human Inquiry
CROSSAB-H282 Recombinant Human Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human VEGFR1 Human Inquiry
IGFV-H282 Recombinant Human Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human VEGFR1 Human Inquiry
BSDB-H282 Recombinant Human Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Diabody) Human Diabody CD3 Human VEGFR1 Human Inquiry
BSFAB-H282 Recombinant Human Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human VEGFR1 Human Inquiry
BSFV-H282 Recombinant Human Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human VEGFR1 Human Inquiry
SCTB-081 Recombinant Anti-VEGFR1 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse VEGFR1 Mouse Inquiry
SCDB-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse VEGFR1 Mouse Inquiry
FABIG-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse VEGFR1 Mouse Inquiry
TRIB-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse VEGFR1 Mouse Inquiry
BSIG-108 Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse VEGFR1 Mouse Inquiry
CROSSAB-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse VEGFR1 Mouse Inquiry
IGFV-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse VEGFR1 Mouse Inquiry
BSDB-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse VEGFR1 Mouse Inquiry
BSFAB-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse VEGFR1 Mouse Inquiry
BSFV-108 Recombinant Anti-CD3 x Anti-VEGFR1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse VEGFR1 Mouse Inquiry

Background

Vascular endothelial growth factor receptor 1 (VEGFR1), a 185kDa tyrosine-protein kinase, operates as a cell membrane surface glycoprotein, which is activated by ligands PGF, VEGFA, and VEGFB. Predominantly enriched in human vascular endothelial cells and various cancer cells, VEGFR1 assumes a pivotal role in regulating angiogenesis, cell migration, cancer cell invasion, cell survival, and macrophage function. Functioning as a negative regulator of embryonic angiogenesis, VEGFR1 effectively inhibits excessive proliferation of endothelial cells. Additionally, VEGFR1 activates downstream MAP kinase and AKT1 signaling pathways. Nowadays, therapeutic drugs targeting VEGFR1 have been developed, exhibiting efficacy in decreasing angiogenesis associated with disorders such as cancers.

Fig.1 The scheme diagram of VEGFR1 signal transduction and tyrosine phosphorylation sites.1

Reference

  1. Koch, Sina, et al. "Signal transduction by vascular endothelial growth factor receptors." Biochemical journal 437.2 (2011): 169-183.
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