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VEGFR3 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H350 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody VEGFR2 Human VEGFR3 Human Inquiry
T-BSDB-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody VEGFR2 Mouse VEGFR3 Mouse Inquiry
SCIGG-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (scIgG) Human Single chain IgGs VEGFR2 Human VEGFR3 Human Inquiry
SCIGG-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scIgG) Human Single chain IgGs VEGFR2 Mouse VEGFR3 Mouse Inquiry
FVTIG-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig VEGFR2 Human VEGFR3 Human Inquiry
FVTIG-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSSG-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (scFv-IgG) Human scFv-IgG VEGFR2 Human VEGFR3 Human Inquiry
BSSG-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scFv-IgG) Human scFv-IgG VEGFR2 Mouse VEGFR3 Mouse Inquiry
IGLFV-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv VEGFR2 Human VEGFR3 Human Inquiry
IGLFV-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSGV-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (IgG-Fv) Human IgG-Fv VEGFR2 Human VEGFR3 Human Inquiry
BSGV-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (IgG-Fv) Human IgG-Fv VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSDG-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Fv-IgG) Human Fv-IgG VEGFR2 Human VEGFR3 Human Inquiry
BSDG-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fv-IgG) Human Fv-IgG VEGFR2 Mouse VEGFR3 Mouse Inquiry
BABFV-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 VEGFR2 Human VEGFR3 Human Inquiry
BABFV-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 VEGFR2 Mouse VEGFR3 Mouse Inquiry
FABVC-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc VEGFR2 Human VEGFR3 Human Inquiry
FABVC-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc VEGFR2 Mouse VEGFR3 Mouse Inquiry
SCDBC-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 VEGFR2 Human VEGFR3 Human Inquiry
SCDBC-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSDBC-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 VEGFR2 Human VEGFR3 Human Inquiry
BSDBC-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 VEGFR2 Mouse VEGFR3 Mouse Inquiry
SCDBF-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc VEGFR2 Human VEGFR3 Human Inquiry
SCDBF-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFVF-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc VEGFR2 Human VEGFR3 Human Inquiry
BSFVF-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSDBF-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc VEGFR2 Human VEGFR3 Human Inquiry
BSDBF-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSTF-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv VEGFR2 Human VEGFR3 Human Inquiry
BSTF-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSCFV-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (scFv-Fc) Human scFv-Fc VEGFR2 Human VEGFR3 Human Inquiry
BSCFV-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scFv-Fc) Human scFv-Fc VEGFR2 Mouse VEGFR3 Mouse Inquiry
MNAB-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Miniantibody) Human Miniantibody VEGFR2 Human VEGFR3 Human Inquiry
MNAB-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Miniantibody) Human Miniantibody VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFC-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 VEGFR2 Human VEGFR3 Human Inquiry
BSFC-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSCC-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL VEGFR2 Human VEGFR3 Human Inquiry
BSCC-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL VEGFR2 Mouse VEGFR3 Mouse Inquiry
BIBD-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Bibody) Human Bibody VEGFR2 Human VEGFR3 Human Inquiry
BIBD-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Bibody) Human Bibody VEGFR2 Mouse VEGFR3 Mouse Inquiry
FABFV-H352 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Fab-Fv) Human Fab-Fv VEGFR2 Human VEGFR3 Human Inquiry
FABFV-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fab-Fv) Human Fab-Fv VEGFR2 Mouse VEGFR3 Mouse Inquiry
MiniB-H353 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Bispecific Antibody (Minibody) Human Minibody VEGFR2 Human VEGFR3 Human Inquiry
MiniB-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Minibody) Human Minibody VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-SAR036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-SAR018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-NGB036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-NGB018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-MEL036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-MEL018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-BGN036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-BGN018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-ABR036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-ABR018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-PAP036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-PAP018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-SAP036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-SAP018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-RTA036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-RTA018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-GEL036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-GEL018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-PE036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-PE018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-DT036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-DT018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFV-SAR036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFV-SAR018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFV-NGB036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFV-NGB018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFV-MEL036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFV-MEL018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFV-BGN036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFV-BGN018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFV-ABR036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFV-ABR018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFV-PAP036 Recombinant Human Anti-VEGFR2 x Human Anti-VEGFR3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Human VEGFR3 Human Inquiry
BSFV-PAP018 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin VEGFR2 Mouse VEGFR3 Mouse Inquiry
SCDB-H350 Recombinant Human Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody VEGFR2 Human VEGFR3 Human Inquiry
FABIG-H350 Recombinant Human Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fab-IgG) Human Fab-IgG VEGFR2 Human VEGFR3 Human Inquiry
TRIB-H352 Recombinant Human Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv VEGFR2 Human VEGFR3 Human Inquiry
BSIG-H350 Human Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (IgG-IgG) Human IgG-IgG VEGFR2 Human VEGFR3 Human Inquiry
CROSSAB-H350 Recombinant Human Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (CrossMab) Human CrossMab VEGFR2 Human VEGFR3 Human Inquiry
IGFV-H350 Recombinant Human Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (IgG-scFv) Human IgG-scFv VEGFR2 Human VEGFR3 Human Inquiry
BSDB-H350 Recombinant Human Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Diabody) Human Diabody VEGFR2 Human VEGFR3 Human Inquiry
BSFAB-H350 Recombinant Human Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Tandem Fab) Human Tandem Fab VEGFR2 Human VEGFR3 Human Inquiry
BSFV-H350 Recombinant Human Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Tandem scFv) Human Tandem scFv VEGFR2 Human VEGFR3 Human Inquiry
SCDB-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody VEGFR2 Mouse VEGFR3 Mouse Inquiry
FABIG-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fab-IgG) Human Fab-IgG VEGFR2 Mouse VEGFR3 Mouse Inquiry
TRIB-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSIG-191 Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (IgG-IgG) Human IgG-IgG VEGFR2 Mouse VEGFR3 Mouse Inquiry
CROSSAB-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (CrossMab) Human CrossMab VEGFR2 Mouse VEGFR3 Mouse Inquiry
IGFV-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (IgG-scFv) Human IgG-scFv VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSDB-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Diabody) Human Diabody VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFAB-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Tandem Fab) Human Tandem Fab VEGFR2 Mouse VEGFR3 Mouse Inquiry
BSFV-191 Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Tandem scFv) Human Tandem scFv VEGFR2 Mouse VEGFR3 Mouse Inquiry

Background

Vascular endothelial growth factor receptor 3 (VEGFR3), encoded by the FLT4 gene in humans and the Vegfr3 gene in the mouse, plays a key role in remodeling the primary capillary plexus in the embryo and contributes to angiogenesis and lymphangiogenesis in the adult. VEGFR3 is synthesized as a 195-kDa precursor protein, proteolytically processed and thought to regulate lymphangiogenesis. It has been identified as a high-affinity receptor for VEGF-C and VEGF-D, which mediate lymphangiogenesis. VEGFR3 is activated by VEGF-C and -D, and proteolytically processed variants may also interact with VEGFR2. VEGFR3 can also promote cell migration and survival in the endothelium of the lymphatic system by protein kinase C (PKC)-dependent activation of MAPK. Blockade of the VEGFR-3 pathway by specific antibodies, soluble receptor constructs, and small molecule kinase inhibitors efficiently inhibits experimental tumor lymphangiogenesis and metastasis and might also represent a novel therapeutic avenue for the treatment of human cancers.

Fig.1 VEGFR3 signalling during lymphangiogenesis and Milroy disease. (Monaghan, 2021) Fig.1 VEGFR3 signaling during lymphangiogenesis and Milroy disease.1

Reference

  1. Monaghan, Richard M., et al. "The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases." Cardiovascular research 117.8 (2021): 1877-1890.
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