Home > Products > BCMA & TACI > Recombinant Anti-BCMA x Anti-TACI Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-BCMA x Anti-TACI Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin)  (BSFAB-GEL001)

Recombinant Anti-BCMA x Anti-TACI Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Gelonin (Gel) fused to a tandem Fab recognizing BCMA and TACI. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver Gel to antigen-specific cells. Then Gel is a type I ribosome-inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Lymphoma therapy.

Specifications

Targets
BCMA & TACI
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
BCMA
Host Animal 1
Mouse
Target 2
TACI
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Lymphoma

Targets

Target 1
BCMA
Gene ID
UniProt ID
Alternative Names
TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCM; BCMA; CD269; TNFRSF13A; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein
Target 2
TACI
Gene ID
UniProt ID
Alternative Names
TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B; CVID; RYZN; TACI; CD267; CVID2; IGAD2; TNFRSF14B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor 13B; transmembrane activator and CAML interactor

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