Recombinant Anti-CD133 x Anti-EGFR Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Gelonin (Gel) fused to a tandem Fab recognizing CD133 and EGFR. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver Gel to antigen-specific cells. Then Gel is a type I ribosome-inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors therapy.
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