Home > Products > CD133 & EGFR > Recombinant Anti-CD133 x Anti-EGFR Tandem Fab-PE immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-CD133 x Anti-EGFR Tandem Fab-PE immunotoxin (Bispecific Immunotoxin)  (BSFAB-PE002)

Recombinant Anti-CD133 x Anti-EGFR Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Pseudomonas exotoxin (PE) fused to a tandem Fab recognizing CD133 and EGFR. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver PE to antigen-specific cells. Then PE can inhibit protein synthesis and kill the target cells. The bispecific immunotoxin is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors therapy.

Specifications

Targets
CD133 & EGFR
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
CD133
Host Animal 1
Mouse
Target 2
EGFR
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors

Targets

Target 1
CD133
Gene ID
UniProt ID
Alternative Names
PROM1; prominin 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen
Target 2
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

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