Home > Products > CD19 & CD22 > Recombinant Anti-CD19 x Anti-CD22 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-CD19 x Anti-CD22 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin)  (BSFAB-SAP003)

Recombinant Anti-CD19 x Anti-CD22 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Saporin (SAP) fused to a tandem Fab recognizing CD19 and CD22. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver SAP to antigen-specific cells. Then SAP is a type I ribosome-inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of B cell lymphoma; Leukemia therapy.

Specifications

Targets
CD19 & CD22
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
CD19
Host Animal 1
Mouse
Target 2
CD22
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
B cell lymphoma; Leukemia

Targets

Target 1
CD19
Gene ID
UniProt ID
Alternative Names
CD19; CD19 molecule; Cluster of differentiation 19; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
Target 2
CD22
Gene ID
UniProt ID
Alternative Names
CD22; CD22 molecule; Cluster of differentiation 22; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2

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