Name: Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin)
SKU: BSFAB-PAP022
Rating: 5 (1 reviews)

Recombinant Anti-CD20 x Anti-CD22 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the pokeweed antiviral protein (PAP) fused to a tandem Fab recognizing CD20 and CD22. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver PAP to antigen-specific cells. Then PAP is a ribosome inhibitory single chain plant toxin and can kill the target cells. The bispecific immunotoxin is designed for the research of Lymphoma; Leukemia; Antoimmune disease; Immune dysfunction disease therapy.

Datasheet INQUIRY

Specifications

Targets

CD20 & CD22

Type

Bispecific Immunotoxin

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Lymphoma; Leukemia; Antoimmune disease; Immune dysfunction disease

Targets

Target 1

CD20

Gene ID

931

UniProt ID

A0A024R507

Alternative Names

MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1

Target 2

CD22

Gene ID

933

UniProt ID

P20273

Alternative Names

CD22; CD22 molecule; Cluster of differentiation 22; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) (CAT#: BSFAB-PAP022)

Specifications

Targets

Customer Reviews and Q&As