Home > Products > CTLA4 & GLUT2 > Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin)

Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin)  (BSFAB-PAP024)

Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the pokeweed antiviral protein (PAP) fused to a tandem Fab recognizing CTLA4 and GLUT2. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver PAP to antigen-specific cells. Then PAP is a ribosome inhibitory single chain plant toxin and can kill the target cells. The bispecific immunotoxin is designed for the research of Renal cell cancer (RCC) therapy.

Specifications

Targets
CTLA4 & GLUT2
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
CTLA4
Host Animal 1
Human
Target 2
GLUT2
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Renal cell cancer (RCC)

Targets

Target 1
CTLA4
Gene ID
UniProt ID
Alternative Names
CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Target 2
GLUT2
Gene ID
UniProt ID
Alternative Names
SLC2A2; solute carrier family 2 (facilitated glucose transporter), member 2; GLUT2; solute carrier family 2, facilitated glucose transporter member 2; glucose transporter type 2, liver

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