Home > Products > CTLA4 & GLUT2 > Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin)  (BSFAB-RTA006)

Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Ricin A chain (RTA) fused to a tandem Fab recognizing CTLA4 and GLUT2. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver RTA to antigen-specific cells. Then RTA can damage ribosomes, inhibit protein synthesis and kill the target cells. The bispecific immunotoxin is designed for the research of Renal cell cancer (RCC) therapy.

Specifications

Targets
CTLA4 & GLUT2
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
CTLA4
Host Animal 1
Mouse
Target 2
GLUT2
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Renal cell cancer (RCC)

Targets

Target 1
CTLA4
Gene ID
UniProt ID
Alternative Names
CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Target 2
GLUT2
Gene ID
UniProt ID
Alternative Names
SLC2A2; solute carrier family 2 (facilitated glucose transporter), member 2; GLUT2; solute carrier family 2, facilitated glucose transporter member 2; glucose transporter type 2, liver

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