Home > Products > EGFR & HER3 > Recombinant Anti-EGFR x Anti-HER3 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-EGFR x Anti-HER3 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin)  (BSFAB-DT010)

Recombinant Anti-EGFR x Anti-HER3 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the diphtheria toxin (DT) fused to a tandem Fab recognizing EGFR and HER3. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver DT to antigen-specific cells. Then DT can inhibit protein synthesis and kill the target cells. The bispecific immunotoxin is designed for the research of Solid tumors therapy.

Specifications
Targets
EGFR & HER3
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Mouse
Target 2
HER3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Solid tumors
Targets
Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
HER3
Gene ID
UniProt ID
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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