Home > Products > EGFR & IGF1R > Recombinant Anti-EGFR x Anti-IGF1R Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-EGFR x Anti-IGF1R Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin)  (BSFAB-NGB011)

Recombinant Anti-EGFR x Anti-IGF1R Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Nigrin b (NGB) fused to a tandem Fab recognizing EGFR and IGF1R. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver NGB to antigen-specific cells. Then NGB is a lectin and can kill the target cells. The bispecific immunotoxin is designed for the research of Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer therapy.

Specifications
Targets
EGFR & IGF1R
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Mouse
Target 2
IGF1R
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer
Targets
Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
IGF1R
Gene ID
UniProt ID
Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

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