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Recombinant Human Anti-EGFR x Human Anti-MET Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin)  (CAT#: BSFAB-ABR026)

Recombinant Anti-EGFR x Anti-MET Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the abrin-a A chain (ABRa-A) fused to a tandem Fab recognizing EGFR and MET. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver ABRa-A to antigen-specific cells. Then ABR is a type II ribosome inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Colorectal cancer; Pancreatic cancer; Head and neck cancer; Non-small cell lung cancer (NSCLC) therapy.
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Specifications

Targets
EGFR & MET
Type
Bispecific Immunotoxin
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer; Pancreatic cancer; Head and neck cancer; Non-small cell lung cancer (NSCLC)

Targets

Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
MET
Gene ID
4233
UniProt ID
A0A024R759
Alternative Names
MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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