Home > Products > gp40 & TFRC > Recombinant Anti-gp40 x Anti-TFRC Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-gp40 x Anti-TFRC Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin)  (BSFAB-SAP012)

Recombinant Anti-gp40 x Anti-TFRC Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Saporin (SAP) fused to a tandem Fab recognizing gp40 and TFRC. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver SAP to antigen-specific cells. Then SAP is a type I ribosome-inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Colon cancer; Ovarian cancer therapy.

Specifications
Targets
gp40 & TFRC
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
gp40
Host Animal 1
Mouse
Target 2
TFRC
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colon cancer; Ovarian cancer
Targets
Target 1
gp40
Alternative Names
gp40; glycoprotein 40; adenocarcinoma-associated antigen
Target 2
TFRC
Gene ID
UniProt ID
Alternative Names
TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90, CD71); IMD46
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