Recombinant Anti-HER2 x Anti-HER3 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) (BSFAB-ABR015)

Recombinant Anti-HER2 x Anti-HER3 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the abrin-a A chain (ABRa-A) fused to a tandem Fab recognizing HER2 and HER3. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver ABRa-A to antigen-specific cells. Then ABR is a type II ribosome inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

Datasheet

Specifications

Targets

HER2 & HER3

Type

Bispecific Immunotoxin

Species Reactivity

Human

Target 1

HER2

Host Animal 1

Mouse

Target 2

HER3

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors

Targets

Target 1

HER2

Gene ID

2064

UniProt ID

P04626

Alternative Names

ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Target 2

HER3

Gene ID

2065

UniProt ID

P21860

Alternative Names

ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Welcome! For price inquiries, we will get back to you as soon as possible.

To order, please email

INQUIRY

Online Inquiry

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

UK
167-169 Great Portland Street, 5th Floor, London, W1W 5PE
Tel: 44-207-097-1828
Email: