Home > Products > HER2 & HER3 > Recombinant Anti-HER2 x Anti-HER3 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-HER2 x Anti-HER3 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin)  (BSFAB-MEL033)

Recombinant Anti-HER2 x Anti-HER3 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Melittin (MEL) fused to a tandem Fab recognizing HER2 and HER3. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver MEL to antigen-specific cells. Then MEL is a cytolytic peptide and can kill the target cells. The bispecific immunotoxin is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

Specifications
Targets
HER2 & HER3
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
HER2
Host Animal 1
Human
Target 2
HER3
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors
Targets
Target 1
HER2
Gene ID
UniProt ID
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Target 2
HER3
Gene ID
UniProt ID
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

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