Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) (BSFV-ABR025)

Recombinant Anti-CTLA4 x Anti-PD1 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the abrin-a A chain (ABRa-A) fused to a tandem scFv recognizing CTLA4 and PD1. It contains a His-tag at the C/N terminus for affinity purification. This bispecific immunotoxin can deliver ABRa-A to antigen-specific cells. Then ABR is a type II ribosome inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of autoimmune disease therapy.

Datasheet INQUIRY

Specifications

Targets

CTLA4 & PD1

Type

Bispecific Immunotoxin

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Autoimmune disease

Targets

Target 1

CTLA4

Gene ID

1493

UniProt ID

P16410

Alternative Names

CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Target 2

PD1

Gene ID

5133

UniProt ID

Q15116

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) (CAT#: BSFV-ABR025)

Specifications

Targets

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