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Recombinant Human Anti-EGFR x Human Anti-HER2 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin)  (BSFV-NGB027)

Recombinant Anti-EGFR x Anti-HER2 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Nigrin b (NGB) fused to a tandem scFv recognizing EGFR and HER2. It contains a His-tag at the C/N terminus for affinity purification. This bispecific immunotoxin can deliver NGB to antigen-specific cells. Then NGB is a lectin and can kill the target cells. The bispecific immunotoxin is designed for the research of Breast cancer; Colon cancer; Lung cancer; Pancreatic cancer; Gastric cancer; Solid tumors therapy.

Specifications

Targets
EGFR & HER2
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Human
Target 2
HER2
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Colon cancer; Lung cancer; Pancreatic cancer; Gastric cancer; Solid tumors

Targets

Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
HER2
Gene ID
UniProt ID
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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