Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) (BSFV-PAP028)

Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the pokeweed antiviral protein (PAP) fused to a tandem scFv recognizing EGFR and HER3. It contains a His-tag at the C/N terminus for affinity purification. This bispecific immunotoxin can deliver PAP to antigen-specific cells. Then PAP is a ribosome inhibitory single chain plant toxin and can kill the target cells. The bispecific immunotoxin is designed for the research of Solid tumors therapy.

Datasheet

Specifications

Targets

EGFR & HER3

Type

Bispecific Immunotoxin

Species Reactivity

Human

Target 1

EGFR

Host Animal 1

Human

Target 2

HER3

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Targets

Target 1

EGFR

Gene ID

1956

UniProt ID

P00533

Alternative Names

EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Target 2

HER3

Gene ID

2065

UniProt ID

P21860

Alternative Names

ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

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