Recombinant Anti-EGFR x Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin)  (BSFV-PAP011)

Recombinant Anti-EGFR x Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the pokeweed antiviral protein (PAP) fused to a tandem scFv recognizing EGFR and IGF1R. It contains a His-tag at the C/N terminus for affinity purification. This bispecific immunotoxin can deliver PAP to antigen-specific cells. Then PAP is a ribosome inhibitory single chain plant toxin and can kill the target cells. The bispecific immunotoxin is designed for the research of Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer therapy.

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