Recombinant Anti-EGFR x Anti-MET Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Melittin (MEL) fused to a tandem scFv recognizing EGFR and MET. It contains a His-tag at the C/N terminus for affinity purification. This bispecific immunotoxin can deliver MEL to antigen-specific cells. Then MEL is a cytolytic peptide and can kill the target cells. The bispecific immunotoxin is designed for the research of Colorectal cancer; Pancreatic cancer; Head and neck cancer; Non-small cell lung cancer (NSCLC) therapy.
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