Home > Products > PDGFR2 & VEGFR2 > Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin)

Recombinant Human Anti-PDGFR2 x Human Anti-VEGFR2 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin)  (BSFV-PAP035)

Recombinant Anti-PDGFR2 x Anti-VEGFR2 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the pokeweed antiviral protein (PAP) fused to a tandem scFv recognizing PDGFR2 and VEGFR2. It contains a His-tag at the C/N terminus for affinity purification. This bispecific immunotoxin can deliver PAP to antigen-specific cells. Then PAP is a ribosome inhibitory single chain plant toxin and can kill the target cells. The bispecific immunotoxin is designed for the research of Cancers therapy.

Specifications

Targets
PDGFR2 & VEGFR2
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
PDGFR2
Host Animal 1
Human
Target 2
VEGFR2
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Cancers

Targets

Target 1
PDGFR2
Gene ID
UniProt ID
Alternative Names
PDGFRA; PDGFR2; platelet derived growth factor receptor, alpha polypeptide; CD140a; Pdgfr-2; AI115593; platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGF-R-alpha; PDGF alpha chain; CD140 antigen-like family member A; platelet-derived growth factor alpha receptor; alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
Target 2
VEGFR2
Gene ID
UniProt ID
Alternative Names
FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; Kinase insert domain receptor; Fetal liver kinase 1; Kinase insert domain receptor, a type III receptor; KDR

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