Name: Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CD19 Trispecific Antibody (Fab-scFv-scFv)
SKU: KLN-1125-LN16
Rating: 5 (1 reviews)

Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CD19 Trispecific Antibody (Fab-scFv-scFv) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-CD3 antibody are both extended with two scFv fragments from an anti-4-1BB antibody and an anti-CD19 antibody. This TsAb has 1+1+1 antigen-binding valency, it provides two signals to activate T cells and recruit them to CD19+ tumor cells. It is designed for the research of B cell lymphoma; Follicular lymphoma; Leukemia therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & 4-1BB & CD19

Type

Fab-scFv-scFv; Trispecific antibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

B cell lymphoma; Follicular lymphoma; Leukemia

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

4-1BB

Gene ID

3604

UniProt ID

Q07011

Alternative Names

CD137; Cluster of Differentiation 137; 4-1BB; 4-1BB Receptor; ILA; Induced by Lymphocyte Activation; T-cell Antigen 4-1BB Homolog; CDw137; IMD109; 4-1BB ligand receptor; Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA

Target 3

CD19

Gene ID

930

UniProt ID

P15391

Alternative Names

CD19; CD19 molecule; Cluster of differentiation 19; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CD19 Trispecific Antibody (Fab-scFv-scFv) (CAT#: KLN-1125-LN16)

Specifications

Targets

Customer Reviews and Q&As