Home > Products > CD3 & 4-1BB & CEA > Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CEA Trispecific Antibody (Fab-scFv-scFv)

Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CEA Trispecific Antibody (Fab-scFv-scFv)  (CAT#: KLN-1125-LN14)

Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CEA Trispecific Antibody (Fab-scFv-scFv) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-CD3 antibody are both extended with two scFv fragments from an anti-4-1BB antibody and an anti-CEA antibody. This TsAb has 1+1+1 antigen-binding valency, it provides two signals to activate T cells and recruit them to CEA+ tumor cells. It is designed for the research of Colorectal cancer (CRC); Breast cancer; Lung cancer; Gastric cancer therapy.
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Specifications

Targets
CD3 & 4-1BB & CEA
Type
Fab-scFv-scFv; Trispecific antibody
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Breast cancer; Lung cancer; Gastric cancer
Host Animal 1
Human
Host Animal 2
Human

Targets

Target 1
CD3
Gene ID
916
UniProt ID
P07766
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
4-1BB
Gene ID
3604
UniProt ID
Q07011
Alternative Names
CD137; Cluster of Differentiation 137; 4-1BB; 4-1BB Receptor; ILA; Induced by Lymphocyte Activation; T-cell Antigen 4-1BB Homolog; CDw137; IMD109; 4-1BB ligand receptor; Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA
Target 3
CEA
Gene ID
1048
UniProt ID
A0A024R0K5
Alternative Names
CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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