Name: Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-MUC17 Trispecific Antibody (Fab-scFv-scFv)
SKU: KLN-1125-LN23
Rating: 5 (1 reviews)

Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-MUC17 Trispecific Antibody (Fab-scFv-scFv) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-CD3 antibody are both extended with two scFv fragments from an anti-4-1BB antibody and an anti-MUC17 antibody. This TsAb has 1+1+1 antigen-binding valency, it provides two signals to activate T cells and recruit them to MUC17+ tumor cells. It is designed for the research of GE Junction Cancer, gastric Adenocarcinoma therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & 4-1BB & MUC17

Type

Fab-scFv-scFv; Trispecific antibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

GE Junction Cancer, gastric Adenocarcinoma

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

4-1BB

Gene ID

3604

UniProt ID

Q07011

Alternative Names

CD137; Cluster of Differentiation 137; 4-1BB; 4-1BB Receptor; ILA; Induced by Lymphocyte Activation; T-cell Antigen 4-1BB Homolog; CDw137; IMD109; 4-1BB ligand receptor; Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA

Target 3

MUC17

Gene ID

140453

UniProt ID

Q685J3

Alternative Names

MUC17; mucin 17, cell surface associated; MUC3; MUC-3; MUC-17; Mucin-17; Small intestinal mucin-3 (MUC-3)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-MUC17 Trispecific Antibody (Fab-scFv-scFv) (CAT#: KLN-1125-LN23)

Specifications

Targets

Customer Reviews and Q&As