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Recombinant Human Anti-CD3 x Anti-CD28 x Anti-CD19 Trispecific Antibody (Fab-scFv-scFv)  (CAT#: KN-1025-N12)

Recombinant Human Anti-CD3 x Anti-CD28 x Anti-CD19 Trispecific Antibody (Fab-scFv-scFv) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-CD3 antibody are both extended with two scFv fragments from an anti-CD28 antibody and an anti-CD19 antibody. This TsAb has 1+1+1 antigen-binding valency, it provides two signals to activate T cells and recruit them to CD19+ tumor cells. It is designed for the research of B cell lymphoma; Follicular lymphoma; Leukemia therapy.
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Specifications

Targets
CD3 & CD28 & CD19
Type
Fab-scFv-scFv; Trispecific antibody
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
B cell lymphoma; Follicular lymphoma; Leukemia
Host Animal 1
Human
Host Animal 2
Human

Targets

Target 1
CD3
Gene ID
916
UniProt ID
P07766
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CD28
Gene ID
940
UniProt ID
P10747
Alternative Names
CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 3
CD19
Gene ID
930
UniProt ID
P15391
Alternative Names
CD19; CD19 molecule; Cluster of differentiation 19; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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