Name: Recombinant Human Anti-CD3 x Anti-CD28 x Anti-HER2 Trispecific Antibody (Fab-scFv-scFv)
SKU: KN-1025-N17
Rating: 5 (1 reviews)

Recombinant Human Anti-CD3 x Anti-CD28 x Anti-HER2 Trispecific Antibody (Fab-scFv-scFv) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-CD3 antibody are both extended with two scFv fragments from an anti-CD28 antibody and an anti-HER2 antibody. This TsAb has 1+1+1 antigen-binding valency, it provides two signals to activate T cells and recruit them to HER2+ tumor cells. It is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

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Specifications

Targets

CD3 & CD28 & HER2

Type

Fab-scFv-scFv; Trispecific antibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

CD28

Gene ID

940

UniProt ID

P10747

Alternative Names

CD28; CD28 molecule; Cluster of Differentiation 28; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen

Target 3

HER2

Gene ID

2064

UniProt ID

P04626

Alternative Names

ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD3 x Anti-CD28 x Anti-HER2 Trispecific Antibody (Fab-scFv-scFv) (CAT#: KN-1025-N17)

Specifications

Targets

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