Name: Recombinant Human Anti-CD3 x Anti-GITR x Anti-HER2 Trispecific Antibody (Single-chain triplebody)
SKU: KLN-1125-LN51
Rating: 5 (1 reviews)

Recombinant Human Anti-CD3 x Anti-GITR x Anti-HER2 Trispecific Antibody (Single-chain triplebody) is designed to be expressed as a single chain with three scFv units for CD3, GITR and HER2. It contains a His-tag at the C/N terminus for affinity purification. This TsAb has 1+1+1 antigen-binding valency, it provides two signals to activate T cells and recruit them to HER2+ tumor cells. It is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & GITR & HER2

Type

Single-chain triplebody; Trispecific antibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

GITR

Gene ID

8784

UniProt ID

Q9Y5U5

Alternative Names

GITR; Glucocorticoid-Induced TNFR-Related protein; TNFRSF18; Tumor Necrosis Factor Receptor Superfamily Member 18; Activation-Inducible TNFR Family Receptor; AITR; CD357 Antigen; CD357; GITR-D; ENERGEN; Glucocorticoid-induced TNFR-related protein; UNQ319/PRO364

Target 3

HER2

Gene ID

2064

UniProt ID

P04626

Alternative Names

ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD3 x Anti-GITR x Anti-HER2 Trispecific Antibody (Single-chain triplebody) (CAT#: KLN-1125-LN51)

Specifications

Targets

Customer Reviews and Q&As