Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C3a anaphylatoxin chemotactic receptor |
| Gene Name | C3AR1 |
| Uniprot | Q16581 (Human); O09047 (Mouse) |
| Synonym | AZ3B; C3AR; HNFAG09; C3a anaphylatoxin chemotactic receptor; complement component 3 receptor 1 |
| Background | C3AR1 (C3aR) is a G protein-coupled receptor protein involved in the complement system. The C3a receptor (C3aR) mediates cellular responses to the complement fragment C3a, a cationic anaphylatoxin implicated in inflammatory cascades and potential anaphylactic reactions. Ligand engagement precipitates receptor conformational shifts, consequently activating coupled heterotrimeric G proteins to initiate downstream signalling pathways. Structurally unique among its G protein-coupled receptor congeners, C3aR features an exceptionally large extracellular domain—exceeding 160 amino acid residues—inserted between the fourth and fifth transmembrane helices (TM4 and TM5). This receptor exhibits significant tissue expression, notably within the central nervous system and across diverse myeloid leukocyte populations, encompassing neutrophils, eosinophils, basophils, mast cells, and cells of the monocyte/macrophage lineage. Subsequently, multiple intracellular kinases and small G proteins are activated, leading to diverse biological actions. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX298 | NativeExtract™ Human C3AR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3608K | MemDX™ Membrane Protein Human C3AR1 (Complement C3a receptor 1) Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0657J | MemDX™ Membrane Protein Human C3AR1 (Complement C3a receptor 1) for Antibody Discovery | HEK293 cells | Full length | N/A |
| MP0142X | MemDX™ Membrane Protein Human C3AR1 (Complement C3a receptor 1) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please contact us for more products or customization | ||||
D***el: I recently purchased the Human C3AR1 Membrane Protein from Creative Biolabs, and I must say, my experience has been nothing short of outstanding. This product has truly exceeded my expectations in every way. The protein is highly active and maintains its structural integrity, which is crucial for my research. The rigorous quality control measures employed by Creative Biolabs are clearly reflected in the product's performance.
24/Jun/2024
N**h: In my experiments, this C3AR1 Membrane Protein has demonstrated exceptional functionality. It has significantly enhanced the accuracy and reliability of my results. Whether it's in binding assays or functional studies, the protein consistently delivers outstanding performance. The high activity levels ensure that even small quantities yield robust and reproducible data.
07/Oct/2023
With our innovative approaches and comprehensive services, Creative Biolabs is dedicated to advancing C3AR1 gene therapy. We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers the Generation of C3AR1 Genetic Models service. We enable the creation of essential genetically modified animal models for interrogating C3AR1 function and its role in pathophysiology. This includes developing C3AR1 knockout lines to elucidate biological consequences stemming from receptor absence, alongside knockin models designed to express specific C3AR1 mutants or tagged variants, thereby permitting detailed investigations into receptor signaling dynamics and molecular interactions in vivo.
Creative Biolabs offers the Vector Systems for C3AR1 Gene Therapy. Support for gene therapy approaches includes the design and production of viral vector delivery systems, frequently employing adeno-associated virus (AAV) platforms recognized for their favorable safety profile and broad tropism. These vectors can be precisely engineered for therapeutic gene delivery, such as constructs mediating targeted C3AR1 gene silencing within specific tissues through RNA interference mechanisms (e.g., shRNA expression).
Creative Biolabs offers comprehensive and innovative services to drive the development of C3AR1 cell therapy. Our commitment to excellence ensures the highest quality and reliability. Please for more services.
Creative Biolabs offers the development service of C3AR1 Cell-Based Therapies. Cellular therapeutic modalities targeting C3AR1 are also facilitated. Our services encompass the genetic modification of pertinent immune effector cells—including neutrophil and macrophage populations—to either conditionally overexpress or ablate C3AR1 function. Subsequent reintroduction of these engineered cells allows for systematic evaluation of their potential for immunomodulation in relevant disease contexts.
Creative Biolabs offers Analytical Support for Therapeutic Strategy. To refine therapeutic strategies, we support sophisticated analyses leveraging pan-cancer datasets to correlate C3AR1 expression levels with immune cell infiltration patterns across various malignancies, aiding the dissection of its context-dependent contributions to tumor immune evasion and therapeutic response.
Creative Biolabs has won a good reputation among our worldwide customers for accomplishing numerous challenging projects including the generation of many functional membrane proteins. Please for more detailed information about our membrane protein preparation services.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
