Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C5a anaphylatoxin chemotactic receptor 1 |
| Gene Name | C5AR1 |
| Uniprot | P21730 (Human); P30993 (Mouse) |
| Synonym | C5A; C5AR; C5R1; CD88; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a-R |
| Background | The complement anaphylatoxin C5a is a strong chemoattractant and an effective inflammatory mediator, which, upon binding to its G protein-coupled membrane-bound receptor C5AR1 provokes and amplifies inflammatory reactions by inducing degranulation, cytokine release, and oxidative burst of immune cells. This receptor is the lynchpin of communication between complement activation and the cellular immune response. The genetic locus for C5AR1 consists of two exons separated by a large intron, a structure it shares with the other anaphylatoxin receptors. It is widely distributed within myeloid cells, and intracellular lymphocyte expression has also been reported. This receptor couples primarily to the Gαi2 in cells such as neutrophils and mast cells. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX407 | NativeExtract™ Human C5AR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0622-KX56 | MemDX™ Recombinant Human C5AR1 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPX0916K | MemDX™ Membrane Protein Human C5AR1 (Complement C5a receptor 1) Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0146X | MemDX™ Membrane Protein Human C5AR1 (Complement C5a receptor 1) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0144X | MemDX™ Membrane Protein Human C5AR1 (Complement C5a receptor 1) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please contact us for more products or customization | ||||
J***an:: The rigorous study of inflammatory pathways and associated pathologies frequently hinges upon access to reliable, high-purity preparations of integral membrane proteins. Specifically, securing dependable sources for the G protein-coupled receptor C5AR1 constitutes a critical experimental requirement for researchers investigating its role in inflammation. Creative Biolabs provides characterized C5AR1 membrane protein products intended to satisfy the demanding quality specifications necessary for advancing immunological research in this area.
21/Mar/2024
A**x: I am very satisfied with Creative Biolabs' C5AR1 Membrane Protein Products. They have significantly enhanced the efficiency and reliability of our research. I would highly recommend them to any researcher working in this field.
04/Oct/2023
With our innovative approaches and comprehensive services, Creative Biolabs is dedicated to advancing C5AR1 gene therapy. We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers gene editing services for the C5AR1 studies. The inhibition of C5AR1 expression through RNA interference (RNAi) or antisense oligonucleotide (ASO) technologies represents a viable post-transcriptional therapeutic approach. Targeted C5AR1 suppression within key cells of the tumor microenvironment (TME), such as resident macrophages and neutrophils, is possible through the creation of advanced delivery systems for oligonucleotide-based agents. Targeted knockdown of C5AR1 signaling within the tumor microenvironment is hypothesized to disrupt local immunosuppressive circuits. The neutralization process leads to improved cytotoxic power of CD8(+) T lymphocytes, which function as vital effectors in antitumor immune responses.
Creative Biolabs offers comprehensive and innovative services to drive the development of C5AR1 cell therapy. Our commitment to excellence ensures the highest quality and reliability. Please for more services.
Creative Biolabs offers C5AR1 functional assays and cell-based models services. Functional interrogation of C5AR1 inhibition impacts on immune cell effector functions can be achieved through methodologies such as competitive peptide blocking experiments. These assays typically involve controlled pre-incubation of relevant immune cell populations with specific C5AR1-blocking peptides prior to assessing downstream sequelae, including alterations in cellular activation markers and quantitative changes in cytokine production profiles.
Creative Biolabs offers the development and preclinical research services for C5AR1-targeted cell therapies. Therapeutic strategies encompassing C5AR1-targeted cell-based immunotherapies are under investigation. One such approach involves the rational design and generation of chimeric antigen receptor (CAR)-T cells engineered to recognize and eliminate C5AR1-expressing cells. This adoptive cell transfer modality holds potential for the selective depletion of C5AR1-positive populations, which may include critical immunosuppressive cell types resident within the tumor microenvironment.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
