Introduction of CACNA2D2
CACNA2D2 is also named as voltage-dependent calcium channel subunit alpha-2/delta-2 which is a protein that in humans is encoded by the CACNA2D2 gene. In addition, it’s a protein which plays a key functional role in the voltage-dependent calcium channel complex. This calcium channel is identified as a calcium influx mediator once membrane polarization happens. The calcium channel complex is formed by alpha-1, alpha-2/delta, beta, and gamma subunits which are composed with a 1:1:1:1 ratio.
|Basic Information of CACNA2D2|
|Protein Name||Voltage-dependent calcium channel subunit alpha-2/delta-2|
|Aliases||Voltage-gated calcium channel subunit alpha-2/delta-2, KIAA0558|
|Organism||Homo sapiens (Human)|
Function of CACNA2D2 Membrane Protein
CACNA2D2 is the alpha-2/delta subunit of voltage-dependent calcium channel complex which can modulate calcium current density, as well as activation or inactivation kinetics of the calcium channel. It plays a critical functional role as a regulatory subunit for N-type (CACNA1B), P/Q-type calcium channel (CACNA1A), as well as L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression of CACNA2D2 can induce apoptosis. It has been reported that CACNA2D2 is important for normal hearing, and it can suppress axon regeneration in the adult CNS. In addition, CACNA2D2 can promote tumorigenesis by stimulating cell proliferation and angiogenesis and is associated with spontaneous Purkinje cell activity.
Fig.1 The heteromultimeric voltage-sensitive Ca2+ channel, which comprises α1, α2δ, β and γ subunits. (Dooley, 2007)
Application of CACNA2D2 Membrane Protein in Literature
This article indicates that except for controlling the expression and gating properties of Cav1.3 channel, the extracellularly localized α2δ2 subunit plays a new role in mediating trans-synaptic alignment of presynaptic Ca2+ channels and postsynaptic AMPA receptors.
This article demonstrates that targeting alpha2delta2 may be a novel treatment strategy to promote structural plasticity and regeneration following CNS trauma.
This study reveals that action of α2δ2 on tumor development occurs not only through a stimulation of proliferation, but also through a stimulation of angiogenesis, via an increased secretion of vascular endothelial growth factor in cells overexpressing α2δ2.
This article reveals the calcium channel function and other roles in synaptogenesis of alpha2delta subunits including α2δ1, α2δ2 and α2δ3.
This article shows that ducky(2J) mutation in Cacna2d2 exhibits a significant reduction in spontaneous Purkinje cell activity and changes the gene expression level.
CACNA2D2 Preparation Options
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