CACNA2D2 Membrane Protein Introduction

Introduction of CACNA2D2

CACNA2D2 is also named as voltage-dependent calcium channel subunit alpha-2/delta-2 which is a protein that in humans is encoded by the CACNA2D2 gene. In addition, it’s a protein which plays a key functional role in the voltage-dependent calcium channel complex. This calcium channel is identified as a calcium influx mediator once membrane polarization happens. The calcium channel complex is formed by alpha-1, alpha-2/delta, beta, and gamma subunits which are composed with a 1:1:1:1 ratio.

Basic Information of CACNA2D2
Protein Name	Voltage-dependent calcium channel subunit alpha-2/delta-2
Gene Name	CACNA2D2
Aliases	Voltage-gated calcium channel subunit alpha-2/delta-2, KIAA0558
Organism	Homo sapiens (Human)
UniProt ID	Q9NY47
Transmembrane Times	1
Length (aa)	1150
Sequence	MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRPTSGPPRPLWLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFYLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSDGPEQCELVQRPRYRRGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVLVHASRRL

Function of CACNA2D2 Membrane Protein

CACNA2D2 is the alpha-2/delta subunit of voltage-dependent calcium channel complex which can modulate calcium current density, as well as activation or inactivation kinetics of the calcium channel. It plays a critical functional role as a regulatory subunit for N-type (CACNA1B), P/Q-type calcium channel (CACNA1A), as well as L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression of CACNA2D2 can induce apoptosis. It has been reported that CACNA2D2 is important for normal hearing, and it can suppress axon regeneration in the adult CNS. In addition, CACNA2D2 can promote tumorigenesis by stimulating cell proliferation and angiogenesis and is associated with spontaneous Purkinje cell activity.

Fig.1 The heteromultimeric voltage-sensitive Ca²⁺ channel, which comprises α1, α2δ, β and γ subunits. (Dooley, 2007)

Application of CACNA2D2 Membrane Protein in Literature

Fell B., et al. α2δ2 Controls the Function and Trans-Synaptic Coupling of Ca_v1.3 Channels in Mouse Inner Hair Cells and Is Essential for Normal Hearing. J Neurosci. 2016, 36(43): 11024-11036. PubMed ID: 27798183

This article indicates that except for controlling the expression and gating properties of Ca_v1.3 channel, the extracellularly localized α2δ2 subunit plays a new role in mediating trans-synaptic alignment of presynaptic Ca²⁺ channels and postsynaptic AMPA receptors.
Tedeschi A., et al. The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Neuron. 2016, 92(2): 419-434. PubMed ID: 27720483

This article demonstrates that targeting alpha2delta2 may be a novel treatment strategy to promote structural plasticity and regeneration following CNS trauma.
Warnier M., et al. CACNA2D2 promotes tumorigenesis by stimulating cell proliferation and angiogenesis. Oncogene. 2015, 34(42): 5383-94. PubMed ID: 25619833

This study reveals that action of α2δ2 on tumor development occurs not only through a stimulation of proliferation, but also through a stimulation of angiogenesis, via an increased secretion of vascular endothelial growth factor in cells overexpressing α2δ2.
Davies A., et al. The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc Natl Acad Sci U S A. 2010,107(4): 1654-9. PubMed ID: 20080692

This article reveals the calcium channel function and other roles in synaptogenesis of alpha2delta subunits including α2δ1, α2δ2 and α2δ3.
Donato R., et al. The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. J Neurosci. 2006, 26(48): 12576-86. PubMed ID: 17135419

This article shows that ducky(2J) mutation in Cacna2d2 exhibits a significant reduction in spontaneous Purkinje cell activity and changes the gene expression level.

CACNA2D2 Preparation Options

We provide custom membrane protein preparation services for worldwide customers. Leveraging by our advanced Magic™ membrane protein production platform, we are able to present target membrane protein in multiple active formats. Our professional scientists are happy to help you find an ideal method and make your project a success. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CACNA2D2 antibody development services.

Creative Biolabs provides high-quality membrane protein preparation service to facilitate the development of worldwide customer’s research. During the past years, we have successfully established a powerful Magic™ membrane protein platform which enables us to provide a series of membrane protein preparation services. For more detailed information, please feel free to contact us.

Reference

Dooley D J, et al. (2007). Ca²⁺ channel alpha2delta ligands: novel modulators of neurotransmission. Trends Pharmacol Sci. 28(2):75-82.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: