Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsIntroduction of CACNB3
CACNB3, also known as voltage-dependent L-type calcium channel subunit beta-3, is encoded by the CACNB3 gene. It belongs to the calcium channel beta subunit family which has been deeply studied during the past few years because it offers numerous possibilities for therapeutic applications. Recent studies show that mutations in the CACNB3 gene are associated with various diseases, such as attention-deficit, hyperactivity disorder, and bipolar disorder.
| Basic Information of CACNB3 | |
| Protein Name | Voltage-dependent L-type calcium channel subunit beta-3 |
| Gene Name | CACNB3 |
| Aliases | CACNLB3 |
| Organism | Homo sapiens (Human) |
| UniProt ID | P54284 |
| Transmembrane Times | Peripheral membrane protein |
| Length (aa) | 484 |
| Sequence | MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWPKDSY |
Function of CACNB3 Membrane Protein
As a voltage-dependent L-type calcium channel, CACNB3 plays a role in the regulation of transcription factors and calcium transport, as well as regulation of the expression and gating of calcium channels. It is one of the four homologous genes coding for the auxiliary Cavβ subunits, which are important modulators of the Ca2+ channel activity. Studies conducted on CACNB3 suggest it can be a potential biomarker for various diseases and provide new ideas for clinical therapy. By an extensive analysis of whole genome sequencing (WGS) in the context of intellectual disability (ID), scientists identify some de novo single nucleotide variants (SNVs) in CACNB3, such as c.1289G > A, which is associated with ID, providing the potential to diagnose idiopathic patients.
Fig.1 Structure of CACNB3 membrane protein.
Application of CACNB3 Membrane Protein in Literature
This article reports that the growth hormone secretagogue receptor type 1a (GHSR), a GPCR, can inhibit the forwarding trafficking of several CaV subtypes, even in the absence of agonist.
This article conducts a whole genome sequencing (WGS) on eight children with idiopathic Intellectual Disability (ID). The result shows that several SNP loci can be targets for ID diagnoses.
Authors in this group conduct a Genome-wide Association Study on Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder patients. These results indicate that a significant single nucleotide polymorphism-based genetic correlation between ADHD and BPD in the full and age-restricted samples.
This article evaluates the expression level of a variety of intercellular proteins, and try to identify the association between proteins and diseases. The data demonstrate that differences in the profile of mRNA encoding a variety of proteins are associated with the generation, conduction and regulation of electrical signals in the sinoatrial node of streptozotocin-induced diabetic rat heart.
This article examines whether loss of function in L-type calcium channels accounts for the attenuated response to lithium in BD cells. The results suggest that calcium signaling is abnormal, and that LTCCs underlie the failure of lithium to amplify circadian rhythms in bipolar disorder patients.
CACNB3 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CACNB3 antibody development services.
As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
