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CACNG2 Membrane Protein Introduction

Introduction of CACNG2

CACNG2 is encoded by CACNG2 gene. It belongs to the neuronal calcium channel gamma subunit subfamily which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. It is one of the five subunits of L-type calcium channels. Recent studies show that CACNG2 has been used as a novel neuropathic pain gene affecting pain susceptibility both in mice and humans.

Basic Information of CACNG2
Protein Name Voltage-dependent calcium channel gamma-2 subunit
Gene Name CACNG2
Aliases MRD10
Organism Homo sapiens (Human)
UniProt ID Q9Y698
Transmembrane Times 4
Length (aa) 323
Sequence MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV

Function of CACNG2 Membrane Protein

CACNG2 is a type I transmembrane AMPA receptor regulatory protein (TARP). It can be expressed in the brain and plays an important role in biological functions, such as synaptic plasticity, learning, and memory. CACNG2 can change the biophysical properties of AMPA receptors in remarkable ways and thus contribute significantly to the functional plasticity of the synapse. Previous research indicates the mouse gamma2 gene (Cacng2) is related with the stargazer mutant mouse line. It can downregulate calcium channel activity by causing a hyperpolarizing shift in the inactivation curve. It is reported that CACNG2 is related to the perception of pain.

Structure of the AMPA receptor. Fig.1 Structure of the AMPA receptor.

Application of CACNG2 Membrane Protein in Literature

  1. Amare A.T., et al. Pharmacogenomics in the treatment of mood disorders: Strategies and Opportunities for personalized psychiatry. EPMA J. 2017, 8(3): 211-227. PubMed ID: 29021832

    This article summarizes the related genes on mood disorders and tries to identify the biomarkers. These results show that several SNPs located at candidate genes that possibly influence response to the treatment on mood disorders, which could be useful for clinical therapy.

  2. Roy B., et al. Zebrafish TARP Cacng2 is required for the expression and normal development of AMPA receptors at excitatory synapses. Dev Neurobiol. 2016, 76(5): 487-506. PubMed ID: 26178704

    This article reveals that the effect of reduced Cacng2a and 2b levels on synaptic physiology on Zebrafish Mauthner cells. The result shows that Cacng2a is required for normal trafficking and function of synaptic AMPARs, while Cacng2b is largely non-functional with respect to the development of AMPA synaptic transmission.

  3. Makharin O.A., et al. MODERN VIEWS ON THE PHARMACOGENETICS OF PAIN. Anesteziol Reanimatol. 2017, 61: 219-223. PubMed ID: 29465208

    Authors in this group summarize a synthesis of literature data about the influence of genetic factors on pain perception and its treatment. The data indicate that some genes, including CACNG2, are related to the perception of pain.

CACNG2 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CACNG2 antibody development services.


As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

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