Introduction of CACNG8
The voltage-dependent calcium channel gamma-8 subunit (CACNG8) is an integral membrane protein encoded by gene CACNG8. The calcium channel gamma subunits comprise an eight-member protein family. Just like CACNG6 and CACNG7, CACNG8 is also a member of voltage, e-dependent calcium channel gamma subunits and usually has a role in stabilizing calcium channels. Its functions are similar to CACNG7.
|Basic Information of CACNG8|
|Protein Name||Voltage-dependent calcium channel gamma-8 subunit|
|Aliases||Neuronal voltage-gated calcium channel gamma-8 subunit, TARP gamma-8, Transmembrane AMPAR regulatory protein gamma-8|
|Organism||Homo sapiens (Human)|
Function of CACNG8 Membrane Protein
CACNG8 is a subunit of the calcium channel gamma subunits, and the calcium channel gamma subunits are part of voltage-gated L-type calcium channels (VLCCs). VLCCs are a group of voltage-gated ion channels found in the membrane of excitable cells. Just like CACNG7, it also has three functions. Firstly, CACNG8 can regulate the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Secondly, CACNG8 can modulate the transport and gating properties of the AMPA-selective glutamate receptor (AMPAR) by slowing down their activation, inactivation and desensitization rates and by modulating their resensitization to promote their targeting to cell membranes and synapses. Thirdly, it can show subunit-specific AMPA receptor regulation.
Fig.1 Expression pattern of CACNG8 gene in situ hybridization in mouse brain coronal sections (Gardinier, 2016)
Application of CACNG8 Membrane Protein in Literature
This article reports that there are many voltage-gated L-type calcium channels (VLCC) in the brain, and genes involved in schizophrenia (SCZ), which encode VLCC subunits, play a role, we have indicated that CACNG8 may cause SCZ risk.
This article reveals that CACNG6, CACNG7 and CACNG8, are located in a tandem array on 19q13.4 and are homologous to CACNG1, CACNG5 and CACNG4.
This article reveals that non-competitive AMPA receptor antagonists may increase the therapeutic index relative to known non-TARP dependent AMPA antagonists, and depends on the presence of TARPγ-8.
This article reveals that The AMPA receptor modulator requires the help of the helper protein CACNG8, also known as the transmembrane AMPA receptor regulatory protein gamma 8 (TARP-γ8).
CACNG8 Preparation Options
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